Sidney Wilkerson-Hill

Dimeric natural products are a unique class of secondary metabolites that possess an array of biological functions, necessitating the development of new, reagent-based approaches for their synthesis…

Cyclopropanes are highly strained carbocycles that are present in drugs, pharmaceuticals, and natural products. This structural motif can impart several beneficial pharmacological properties such as increased potency, decreased lipophilicity, alteration of p_K_a, and binding favorability…

Complex secondary metabolites isolated from natural sources (i.e. natural products) provide a wealth of diverse chemical space and often serve as the basis for drug development…

Cyclopropanes are prototypical strained sp3-rich carbocycles that have captivated chemists due to their myriad applications imparted by their inherent strain and conformational rigidity…

Given the widespread presence of nitrogen-containing heterocycles in active pharmaceutical ingredients, methods for their synthesis are of paramount importance…

The synthesis of cyclopropanes is of contemporary interest due to their ubiquity in small molecule pharmaceuticals and agrochemicals as well as their use as synthetic intermediates…

α-Halonitriles are common intermediates in organic synthesis due to their utilization as masked ketones…

_Gem_-disubstituted cyclopropanes are a ubiquitous motif found in biologically active compounds such as the pyrethroids, an important class of compounds in the agrochemical industry…

Cyclopropanes are strained sp3-rich carbocycles that have captivated chemists due to their myriad applications in pharmaceutical development, chemical biology, and materials science…

DIVISION/COMMITTEE: [ORGN] Division of Organic Chemistry

DIVISION/COMMITTEE: [ORGN] Division of Organic Chemistry

Carbenes are important synthetic intermediates that enable transformations in fields ranging from chemical biology to medical chemistry and material sciences. Thus, new innovations to advance the chemistry of divalent carbon are critical…

The synthesis of highly strained molecules (i.e. > 27 kcal/mol strain energy) is becoming an important component of medicinal chemistry programs, because these compounds increase the fraction of sp3 hybridized carbon atoms (Fsp3) of molecules and have well-defined exit vectors…