Christopher Uyeda

From laboratory-scale syntheses of bioactive compounds to industrial-scale processes that deliver basic chemicals, transition metal catalysis plays a key role in how molecules are built in the modern world…

Organozincs are very important organometallic reagents due to their reactivity with various electrophiles and greater functional group tolerance. Most of the synthetic route uses alkyl halides and zinc species to form the organozinc…

Catalytic isomerizations of double bonds typically occur through chemical modification of the bond, such as the reversible addition of a metal hydride…

Division/Committee: [INOR] Division of Inorganic Chemistry

Ring strain is the driving force for numerous ring-opening reactions of 3- and 4-membered heterocycles. By comparison, 5-membered heterocycles lack this thermodynamic driving force…

Alkyl diazene compounds serve an important role as a precursor for the generation of tertiary radicals, which find use in a range of applications such as initiators for radical polymerization and coupling partners for the formation of sterically encumbered quaternary centers…

Although the Simmons–Smith reaction was first reported over fifty years ago, it remains one of the most relevant methods for cyclopropanation today. Asymmetric variants of the Simmons-Smith are rare and often limited to allylic alcohols as substrates…

Most metal catalyzed alkene cyclopropanation reactions involve the generation of an electrophilic metal carbene from a diazo precursor. By contrast, cyclopropanations of electron-deficient alkenes are often carried out using the Corey–Chaykovsky reaction…

Kinabalurine, incarvilline, tecomanine, and skytanthine contain stereochemically complex [4.3.0]-azabicycles and belong to the diverse monoterpene alkaloid family of natural products…

Carbenes are versatile reactive intermediates that display orthogonal reactivity to common nucleophilic and electrophilic functional groups…

From laboratory-scale syntheses of bioactive compounds to industrial-scale processes that deliver basic chemicals, transition metal catalysis plays a key role in how molecules are built in the modern world…

: [CATL] Division of Catalysis Science & Technology

From laboratory-scale syntheses of bioactive compounds to industrial-scale processes that deliver basic chemicals, transition metal catalysis plays a key role in how molecules are built in the modern world…

: [CATL] Division of Catalysis Science & Technology

From laboratory-scale syntheses of bioactive compounds to industrial-scale processes that deliver basic chemicals, transition metal catalysis plays a key role in how molecules are built in the modern world…

: [CATL] Division of Catalysis Science & Technology

From laboratory-scale syntheses of bioactive compounds to industrial-scale processes that deliver basic chemicals, transition metal catalysis plays a key role in how molecules are built in the modern world…

: [CATL] Division of Catalysis Science & Technology

From laboratory-scale syntheses of bioactive compounds to industrial-scale processes that deliver basic chemicals, transition metal catalysis plays a key role in how molecules are built in the modern world…

Organozincs are very important organometallic reagents due to their reactivity with various electrophiles and greater functional group tolerance. Most of the synthetic route uses alkyl halides and zinc species to form the organozinc…

Catalytic isomerizations of double bonds typically occur through chemical modification of the bond, such as the reversible addition of a metal hydride…

DIVISION/COMMITTEE: [INOR] Division of Inorganic Chemistry

Ring strain is the driving force for numerous ring-opening reactions of 3- and 4-membered heterocycles. By comparison, 5-membered heterocycles lack this thermodynamic driving force…

Alkyl diazene compounds serve an important role as a precursor for the generation of tertiary radicals, which find use in a range of applications such as initiators for radical polymerization and coupling partners for the formation of sterically encumbered quaternary centers…

Although the Simmons–Smith reaction was first reported over fifty years ago, it remains one of the most relevant methods for cyclopropanation today. Asymmetric variants of the Simmons-Smith are rare and often limited to allylic alcohols as substrates…

Most metal catalyzed alkene cyclopropanation reactions involve the generation of an electrophilic metal carbene from a diazo precursor. By contrast, cyclopropanations of electron-deficient alkenes are often carried out using the Corey–Chaykovsky reaction…

Kinabalurine, incarvilline, tecomanine, and skytanthine contain stereochemically complex [4.3.0]-azabicycles and belong to the diverse monoterpene alkaloid family of natural products…

Carbenes are versatile reactive intermediates that display orthogonal reactivity to common nucleophilic and electrophilic functional groups…

DIVISION/COMMITTEE: [ORGN] Division of Organic Chemistry

Carbenes are versatile reactive intermediates that display orthogonal reactivity to common nucleophilic and electrophilic functional groups…

DIVISION/COMMITTEE: [ORGN] Division of Organic Chemistry

Lysine 5,6-aminomutase (5,6-LAM) utilizes adenosylcobalamin (AdoCbl) and pyridoxal-5'-phosphate (PLP) to mediate the challenging 1,2 rearrangement of a terminal amine via a radical-based mechanism controlled and initiated by large-scale domain shifts within the protein complex…

From laboratory-scale syntheses of bioactive compounds to industrial-scale processes that deliver basic chemicals, transition metal catalysis plays a key role in how molecules are built in the modern world…

Azoarenes are an important class of organic dye molecules that have seen a resurgence of interest due to their photoswitching properties…