Rulin Zhao
Appearances
- DateMarch 20, 2022The toll-like receptors (TLRs) are a family of pattern recognition receptors utilized by the innate immune system for detection of molecules associated with infection and stress, resulting in immune upregulation…
Presenter
Bristol-Myers SquibbSpeakers
Scientific Director, Bristol Myers Squibb - DateAugust 21, 2022The toll-like receptors (TLRs) are integral to the innate immune system, serving as pattern recognition receptors for the early detection of molecular signatures presented by pathogenic sources such as bacteria and viruses…
Presenter
Scientific Director, Bristol Myers SquibbSpeakers
Bristol-Myers Squibb - DateMarch 29, 2023The innate immune system employs toll-like receptors (TLRs) to identify signs of cellular stress and infection through the recognition of damage-associated and pathogen-associated molecular patterns, resulting in upregulation of immune pathways…
Presenter
Bristol-Myers SquibbSpeakers
Scientific Director, Bristol Myers Squibb - DateAugust 21, 2024ABSTRACT: (-)-(1_R,_2_S,_3_R,_4_R,Z_)-7-(Bromomethylene)-N-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(2,2,2-trifluoroacetamido)bicyclo[2.2.1]heptane-2-carboxamide (TITLE COMPOUND (-)-1) was identified as a divergent scaffold for comprehensive SAR studies in a drug discovery programs…
- DateAugust 21, 2025Bruton’s tyrosine kinase (BTK), a non-receptor tyrosine kinase and member of the Tec family of kinases, is essential for antigen-specific BCR-mediated functions and signaling through the Fc-gamma receptors for the IgG-containing immune complexes in monocytic cells…
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