The toll-like receptors (TLRs) serve key roles in the innate immune system through their recognition of pathogen- and danger-associated molecular patterns (PAMPs/DAMPs)…
The toll-like receptors (TLRs) are a family of pattern recognition receptors utilized by the innate immune system for detection of molecules associated with infection and stress, resulting in immune upregulation…
A primary defect in lupus patients is the accumulation of apoptotic debris enriched in RNA ligands capable of activating TLR7 and TLR8, especially as the ligands form immune complexes with pre-existing autoantibodies…
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple tissues and organs including the joints, skin, and kidneys…
The toll-like receptors (TLRs) serve key roles in the innate immune system through their recognition of pathogen- and danger-associated molecular patterns (PAMPs/DAMPs)…
The toll-like receptors (TLRs) are integral to the innate immune system, serving as pattern recognition receptors for the early detection of molecular signatures presented by pathogenic sources such as bacteria and viruses…
Pattern recognition receptors (PRRs) of the innate immune system are an important part of frontline immune surveillance, recognizing signals from infection and cellular stress…
The Toll-Like Receptors (TLRs) play key roles in activation of the innate immune system following detection of pathogen- or danger-associated molecular patterns (PAMPs/DAMPs) produced by microbial sources or by host cells when stressed or damaged…
The innate immune system employs toll-like receptors (TLRs) to identify signs of cellular stress and infection through the recognition of damage-associated and pathogen-associated molecular patterns, resulting in upregulation of immune pathways…
Toll-like receptor 7 and 8 (TLR7/8) play crucial roles in regulation of innate immunity and are promising targets for therapeutic intervention in autoimmune diseases…