Mariur Rodriguez Moreno

Peptide-based catalysts offer a unique platform to perform bifunctional catalysis. However, they are somewhat limited in scope as most rely on amino acids to catalyze reactions. We envision the development of a general catalytic platform that can be used with a wide variety of catalysts…

Transition metal-catalyzed C-N bond-forming reactions are a staple of modern organic synthesis. In particular, the Buchwald-Hartwig amination reaction is a versatile process for C–N cross-couplings and many research efforts have focused on modifications to this reaction…

The misregulation of protein levels in cells is an important factor that controls cell growth and metastasis in cancer. For example, the upregulation of sphingosine kinase 1 (SK1) is responsible for increased cell proliferation in many cancer types…

Proteolysis Targeting Chimeras (PROTACs) are dual-ended molecules that bind to a target protein and an E3 ligase, and in turn downregulate the target protein via polyubiquitination. Our research consists of the bioanalysis of 8 novel PROTACs in PSN1 pancreatic cancer cells…

Proteolysis Targeting Chimeras (PROTACs) are bifunctional molecules that repurpose preexisting cellular machinery to bind, ubiquitinate, and downregulate target protein concentrations…

Cross coupling catalysis, including for the Suzuki, Heck, Sonogashira, Stille, Negishi, and aryl

Protein targeted chimeras (PROTACs) are bifunctional molecules that bind a protein of interest (POI) and an E3 ligase at the same time. This dual interaction brings the E3 ligase into proximity with the POI to facilitate polyubiquitination and subsequent degradation of the POI…

The amination of aryl halides is an important cross-coupling reaction because of the importance of aniline derivatives in pharmaceutical research…

The Buchwald-Hartwig amination is one of the most important reactions for pharmaceutical synthesis because it allows for the efficient formation of C–N bonds on aromatic rings…

Studies show that up-regulation of the protein sphingosine kinase 1 (SPHK1) contributes to increased proliferation and stress resistance in pancreatic cancer…

Sphingosine kinase 1 (SphK1) is involved in various cellular processes including cell growth, survival, migration, angiogenesis, and catalysis of the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P)…

A metal-metal interaction in an organometallic complex can dramatically influence reaction mechanisms, reactivity, and selectivity during catalysis…

Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit the cell’s natural machinery to induce proteasomal degradation of a target protein in a catalytic manner…

Aryl amination, or Buchwald-Hartwig amination, is widely used in synthetic and pharmaceutical chemistry…

The misregulation of proteins in the human body is a significant cause of many diseases including cancers. Cancer cells often upregulate proteins that signal cell growth and metastasis…