Peptide-based catalysts offer a unique platform to perform bifunctional catalysis. However, they are somewhat limited in scope as most rely on amino acids to catalyze reactions. We envision the development of a general catalytic platform that can be used with a wide variety of catalysts…
Peptide stapling is a method to covalently modify peptide-based drugs in order to increase their pharmacological properties. Stapling can increase proteolytic stability as well as change their solubility and permeability properties…