Dr. Julia Brumaghim
Professor, Clemson University
Dr. Brumaghim earned her PhD in Chemistry with Dr. Greg Girolami at the University of Illinois, Urbana and completed post-doctoral work with Drs. Ken Raymond (Chemistry) and Stuart Linn (Molecular and Cellular Biology) at the University of California, Berkeley. At Clemson University, Dr. Brumaghim has examined the ability of antioxidants to prevent metal-mediated oxidative damage, damage that leads to cardiovascular diseases, cancer, and neurodegenerative diseases. Due to the lack of readily deployable tools to study such damage and a lack of understanding about cellular metal-based processes, metal-mediated oxidative DNA damage is often overlooked. Dr. Brumaghim develops tools to quantify antioxidant prevention of metal-mediated DNA damage and has demonstrated the first structure-activity relationships for a variety of antioxidant classes. She also explores mechanisms of nanoparticle toxicity, radical-induced radiation damage, and antifungal drug resistance development.
Appearances
DateAugust 23, 2021Iron-mediated oxidative DNA damage is an underlying cause of cardiovascular diseases and tissue death in ischemic stroke…Speakers
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- DateAugust 24, 2021Division/Committee: [INOR] Division of Inorganic Chemistry
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Professor of Chemisrtry, SUNY Stony BrookPresider
Professor, Clemson University 
DateAugust 24, 2021Our understanding of metal ions and metal oxide nanoparticles in biological and toxicological oxidative damage contexts continues to evolve…Presenter
Professor, Clemson University- DateAugust 24, 2021DNA-bound Fe(II) generates hydroxyl radical that causes single-strand backbone nicks. DNA-localized antioxidants could shield DNA from hydroxyl radical damage but this requires targeting antioxidants to the DNA…
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Professor, Clemson UniversityPresenter
- DateAugust 25, 2021Vanadyl is an attractive, earth-abundant first row transition metal oxidant, but could benefit from improved solubility in organic solvents and control of stereochemical outcome…
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Clemson UniversitySpeakers
Professor, Clemson University - DateAugust 23, 2021_N_-Heterocyclic thiones are common motifs in pharmaceuticals such as methimazole and enzalutamide as well as antifungals such as prothioconazole…
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Professor, Clemson University - DateAugust 23, 2021Cellular oxidative stress and DNA damage is caused by the Fenton and Fenton-like reactions where Fe(III) and Cu(II), respectively, react with hydrogen peroxide to produce damaging hydroxyl radical…
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Undergraduate Researcher, Clemson UniversitySpeakers
Professor, Clemson University - DateAugust 25, 2021As the most abundant intracellular antioxidant, glutathione (GSH) has been extensively studied for its roles in hydrogen peroxide reduction and other enzymatic pathways, but it has not been well studied for its metal binding properties…
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Professor, Clemson University 
DateAugust 24, 2021Recent literature on how the COVID-19 pandemic has affected scientists has highlighted three categories of scientists whose careers have been most negatively impacted: women, bench scientists, and those with young children…Presenter
Professor, Clemson University- Hydroxyl radical formation by Fe(II) or Cu(I) and hydrogen peroxide leads to oxidative DNA damage, an underlying cause of neurodegenerative and cardiovascular diseases. Specifically, oxidative damage to the deoxyribose sugar causes DNA strand breaks…
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Professor, Clemson University - The PUREX (Pu and U Reduction Extraction) process commonly uses tributyl phosphate (TBP) as the extractant to separate out uranium and plutonium from nuclear waste…
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Clemson UniversityProfessor, Clemson University - DateMarch 29, 2023Hydroxyl radical formation by Fe(II) or Cu(I) and hydrogen peroxide leads to oxidative DNA damage, an underlying cause of neurodegenerative and cardiovascular diseases. Specifically, oxidative damage to the deoxyribose sugar causes DNA strand breaks…
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Professor, Clemson University - DateMarch 26, 2023Covalency of An(III) and Ln(III) can be explored using ligands containing soft donor atoms such as sulfur and selenium, whose orbitals should overlap more extensively with the radially extended 5f orbitals of actinides compared to the 4f orbitals of lanthanides…
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- DateMarch 27, 2023The PUREX (Pu and U Reduction Extraction) process commonly uses tributyl phosphate (TBP) as the extractant to separate out uranium and plutonium from nuclear waste…
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Clemson UniversityProfessor, Clemson University - DateAugust 18, 2024CHON-only extractants such _N,N_-di-2-ethylhexyl-isobutyramide (DEH_i_BA) as are a high priority for nuclear waste separations to facilitate incineration, minimize third-phase formation, and counter proliferation by only enabling uranium separation…
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Clemson UniversityProfessor, Clemson University
