Thinh Tran

Scientists have spent a considerable amount of time and effort designing a pre-catalyst that transforms into the active catalytic species upon entry into the reaction. Scientist typically consider stability and reactivity when designing a pre-catalyst…

Mechanochemistry is a solventless approach for neat synthetic chemistry; the reaction kinetics are driven by mechanical forces (e.g. sheering, grinding, collisions). This enables the development of new chemical routes. In addition, the absence of solvent lowers generated waste and costs…

We report a solvent-free Sonogashira coupling of para-substituted aryl halides with trimethylsilyl acetylene or phenylacetylene using a palladium catalyst and a copper (0) co-catalyst under mechanochemical conditions…