Rebecca Abergel

Division/Committee: [INOR] Division of Inorganic Chemistry

Division/Committee: [INOR] Division of Inorganic Chemistry

From potential contamination of individuals with radioactive fission products after a nuclear accident to the therapeutic use of radioisotopes for cancer diagnostics and treatment, the biological chemistry of actinides is not only relevant to a number of applied problems, it has also revealed some…

Division/Committee: [INOR] Division of Inorganic Chemistry

Developing targeted alpha-therapy to treat diseases has potential for transformative impact, worldwide…

Division/Committee: [NUCL] Division of Nuclear Chemistry and Technology

The future of nuclear medicine would appear to be the paradigm of personalized medicine — targeted radionuclide therapy to spare healthy tissue, and theranostic medicine, which pairs an imaging isotope with a therapeutic isotope to provide simultaneous, real-time dose delivery and verification, lea…

Division/Committee: [NUCL] Division of Nuclear Chemistry and Technology

Actinium-225 (t1/2 = 9.9 days) and thorium-227 (t1/2 = 18.7 days) are the preeminent candidates for Targeted Alpha Therapy (TAT), where alpha-emitting radionuclides are chemically coupled to targeting vectors in order to deliver high linear energy transfer (LET) radiation to nearby tissue…

Division/Committee: [PMSE] Division of Polymeric Materials Science and Engineering

Gadolinium-based contrast agents are widely used in magnetic resonance imaging procedures to enhance image contrast. Despite their ubiquitous use in clinical settings, gadolinium is not an innocuous element, as suggested by several disorders associated with its use…

While periodic trends have been used to approximate the reactivity of francium, the largest group 1 element (Z = 87), there is little experimental data to confirm its theoretical properties…

Water-soluble hydroxypyridinone-based chelators have opened new avenues over the past few years for the effective complexation of actinide and lanthanide elements in various fundamental coordination and biomedical studies…

Division/Committee: [ENFL] Division of Energy and Fuels

Selectivity in rare earth (RE) metal separations is largely governed by the ionic radii of the metal ions in the +3-oxidation state…

Prior to the Antibiotic Era, infectious disease was leading cause of human morbidity and mortality throughout human history. However, with the advent of the first antibiotics pathogens evolved resistance mechanisms…

The threat of a major radiological event presents a danger of not only large-scale external radiation exposure of the population but also internal contamination with radionuclides, including actinides and lanthanide fission products…

Targeted α-therapy (TAT), a branch of nuclear medicine in which α-emitting radioisotopes are localized to diseased tissue and deliver damaging radiation via the use of a biological targeting vector, has the potential to transform how diseases are treated…

The transplutonium elements, e.g. the heavy actinides, are less well understood than the earlier members of the actinide series due to their extremely limited availability and high radioactivity…

Targeted α-therapy (TAT), a branch of nuclear medicine in which α-emitting radioisotopes are localized to diseased tissue and deliver damaging radiation via the use of a biological targeting vector, has the potential to transform how diseases are treated…

The transplutonium elements, e.g. the heavy actinides, are less well understood than the earlier members of the actinide series due to their extremely limited availability and high radioactivity…

Exposure to radioactive contaminants from explosive devices poses serious health risk to military personnel, particularly long-term exposure to inhaled particulates…

Targeted alpha therapy (TAT) strategically delivers alpha-emitting radioisotopes to cancerous cells through biological targeting vectors. In particular, actinium-225 (225Ac; t1/2 = 9.92 days) TAT has garnered significant interest with promising clinical studies…

Come learn more about actinide research opportunities at the National Laboratories. The Seaborg Institute directors will be hosting a session to discuss research opportunities in actinides chemistry…

Over the past decade, select isotopes of the lanthanide and actinide series of elements have emerged as promising therapeutic and/or diagnostic radiometals…

The remarkably strong chelation of tetravalent _f_-elements by 3,4,3-LI(1,2-HOPO), denoted HOPO herein, lies at the center of research efforts in fields spanning from radiopharmaceuticals to fundamental _f_-element chemistry…

Lanthanides (Lns) and actinides (Ans) exhibit unique properties, which have made them essential to technological advancements in the energy, medical, materials, and catalysis industries. Unfortunately, these metals are extremely difficult to separate and recycle…

In contrast to the uranium-plutonium (U-Pu) nuclear fuel cycle, the thorium (Th) fuel cycle is attractive due to the natural abundance of Th, perceived reduction of long-lived radioactive waste, and greater resistance to the proliferation of fissile materials…

The energetic interplay between the nearly-degenerate 5f and 6d orbitals in the actinide series gives rise to chemical and physical properties that are not observed elsewhere in the periodic table…

Circularly polarized luminescence (CPL) is the emission of chiral light and has several sensing applications including bank note encryption. Luminescent lanthanides and actinides possess unique electronic properties, which through strategic ligand design can generate highly emissive complexes…

In the past few decades, lanthanides have emerged as an important area of research with applications in medicine, electronics, counterfeit and other areas, but there is more to learn about fundamental lanthanide chemistry and interactions in biological environments…

DIVISION/COMMITTEE: [NUCL: Division of Nuclear Chemistry and Technology]