Michael Doyle

The formation of nitrile oxides with diazocarbonyl compounds by nitrosyl transfer from _tert_-butyl nitrite under mild conditions and without the use of a catalyst or an additive is reported…

Copper catalyzed difunctionalization of alkenes provides carbocyanation, carboazidation and carbothiocyanation of alkenes through the selective abstraction of a halogen atom (X) by _α_-aminoalkyl radicals…

Bob Lichter was a candidate for the 2004 ACS Board of Directors for which his candidacy statement included the statement: "Diversity and inclusiveness remain watchwords of strength in the chemical sciences…

The catalytic use of metal carbenes for addition, insertion, and cycloaddition reactions is dependent on their carbene precursor…

1,2,3-Triazine 1-oxides are remarkably effective substrates for inverse electron demand Diels−Alder reactions…

The first report that a homogeneous chiral catalyst could be used for asymmetric induction was buplished in 1966 by Nozaki and coworkers that included R. Noyori…

Cesium carbonate driven reactions of β-ketoesters with 1,2,3-triazine 1-oxides generates 2-pyridones in good to high yield, instead of the sole formation of pyridines when the same reaction is performed in the presence of other alkali metal carbonates or organic bases…

1,2,3-Triazine and 1,2,3-triazine 1-oxide are susceptible to nucleophilic addition due to presence of polarized electron density over aromatic ring…

Heterocyclic rings are important structural scaffolds encountered in both natural and synthetic compounds, and their biological activity often depends on these motifs. They are predominantly accessible _via_ cycloaddition reactions, realized by either thermal, photochemical, or catalytic means…

Natural products have a wide structural variety of functional groups, as well as heteroatomic rings, that provide different biological activities. Structural modifications of these compounds have demonstrated an increase in their biological activities…

A novel series of 1,2,3-triazine 1-oxide (2A-T) substituted at 5 position have been synthesized by the condensation of ketones (-Ph, _p_-CF3Ph-, _p_-ClPh-, _p_-BrPh-, _p_-FPh-, Et-, etc) with ethyl diazoacetate to obtain vinyl analogues that were subsequently transformated into triazines…

A series of twenty 1,2,3-triazine 1-oxide derivatives were sythesized through the 5+1 cycloadition reaction between a diverse set of vinyl diazo-compounds and tert-butyl nitrite…

Tuberculosis (TB) is one of the leading cause of dead mainly produced by the infectious agent _Mycobacterium tuberculosis_. The most common form of TB affects the lungs. It is estimated that 10.8 million people are infected with TB worldwide…

Parasitic diseases are considered neglected tropical diseases, for example Chagas disease or Leishmaniasis, caused by _Trypanosoma sp_ and _Leishmania sp_ respectively…