Luigi Agrofoglio

Acyclo nucleosides phosphonates represent a major class of antiviral drugs. Among them, Tenofovir®, an active antiviral against the human immunodeficiency virus (HIV) and the hepatitis B virus (HBV), shows nephrotoxicity and poor bioavailability…

(Re)emerging RNA viruses such as Severe Acute Respiratory Syndrome (SARS), Zika, Dengue, Chikungunya, H1N1 influenza and Ebola have been major threats to public health in the past years, for which only few drugs are available…

Acyclo nucleosides phosphonates represent a major class of antiviral drugs. Among them, Tenofovir®, an active antiviral against the human immunodeficiency virus (HIV) and the hepatitis B virus (HBV), shows nephrotoxicity and poor bioavailability…

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic positive-sense RNA virus responsible for the novel viral pandemic COVID-19…

Acyclonucleoside phosphonates (ANP) pro-drugs have shown to be active against various DNA, RNA and retroviruses. These ANP derivatives improved cell penetration and decreased nephrotoxicity…

STING protein is the most important adaptor _PROTEIN_ in immune response. Herein we report on the synthesis of small libraries of hitherto unknown new heterocycles bearing either an oxazolo[5,4-d]pyrimidine and a benzimidazole moiety, respectively…

STING protein is a unique and pivotal protein of cGAS-STING signaling pathway; its modulation is involved in immunity and STING is considered as a new attractive target to treat infections and cancers…

Acyclo nucleosides phosphonates (ANP) represent an important class of antiviral drugs. Among them, Tenofovir®, an antiviral active against human immunodeficiency virus (HIV) and the hepatitis B virus (HBV) has nephrotoxicity and poor bioavailability…

With the world's population growing exponentially and estimated to reach 9.7 billion by 2050, commercial exchanges are increasing and the environment for wild animals is being reduced, new viruses are being discovered every year, particularly RNA viruses, for which only few drugs are available…

DIVISION/COMMITTEE: [ORGN: Division of Organic Chemistry]

DIVISION/COMMITTEE: [ORGN: Division of Organic Chemistry]