Joanna Burdette

The verticillins, a class of epipolythiodioxopiperazine alkaloids (ETP) have gained attention due to their potent activity against cancer cells, noted both in vitro and in vivo…

The flavaglines, isolated from the plant genus _Aglaia_, constitute a class of natural products that are defined by the presence of a characteristic cyclopenta[_b_]benzofuran core…

Ovarian cancer is the most fatal of all female reproductive cancers with a 5-year survival rate below 50%. Over 90% of diagnosed ovarian cancers are categorized as epithelial white germ cell cancer…

Silvestrol and its analogues represent a variant of flavaglines in having a 1,4-dioxanyloxy ring attached at C-6 of the cyclopenta[_b_]benzofuran core…

The phyllanthusmins belong to the arylnaphthalene subclass of lignan lactone natural products, which have historically been reported to have a wide range of biological activities, including anticancer, antiviral, and insecticidal properties…

Well-recognized for modulating eukaryotic spliceosome activity, pladienolides belong to a select group of polyketide natural products that have been a focus of recent synthetic and bioactivity studies. However, our understanding of their biosynthesis is still limited…