Jay Larrow

Bioisosteres are ubiquitous in medicinal chemistry and are used to manipulate the physicochemical properties or metabolism of a drug lead. Due to our group’s interest in ladderane-containing natural product synthesis, we present syntheses to bicyclo[2.2…

Medicinal chemists use isosteres in the form of atoms or functional groups to manipulate the physicochemical properties or metabolism of a drug lead. While there have been numerous examples of _para-_substituted aromatic ring isosteres, those for the _meta_-substitution are rare…