The accreditors of this session require that you periodically check in to verify that you are still attentive.
Please click the button below to indicate that you are.
3973023
Tellurium-based zinc ion transporters assisted by intramolecular chalcogen bonding
Date
March 20, 2024
Explore related products in the following collection:
In the context of our ongoing exploration into the Lewis acidity of main group elements and their potential for ion transport applications, we have developed a series of antimony- and tellurium-based transporters. This presentation aims to delineate a unique class of electron-poor aryl telluride adorned with a flanking dipicolylamine (DPA) ligand. These novel compounds, characterized by the LP(N)→σ*(Te-C) chalcogen bond, have been evaluated for their capability to transport Zn2+ ions. UV-vis titration and NBO analyses demonstrate that the aforementioned chalcogen bond diminishes the DPA’s affinity for Zn2+ ions, thereby enhancing the likelihood of facile release. This inference finds support in U-tube Zn2+ transport assays, revealing a direct correlation between the strength of the LP(N)→σ*(Te-C) chalcogen bond and the efficiency of these compounds as zinc ion transporters. This assertion is further substantiated by results from S and Se analogs, which exhibit greater Zn2+ ion binding affinity as evidenced by their limited transport activity. Collectively, these findings underscore the utility of chalcogen bonding as a valuable tool for tailoring the properties of Zn2+ ion transporters.
The properly regulated transport of anions is an important feature of cellular homeostasis, while dysregulated anion transport can give rise to serious disease…
With the aim of studying the interaction of gold with a Lewis acidic antimony fragment supported by an _N_-heterocyclic carbene backbone, the synthesis of an indazolium-stibine ligand ([1]CL) and its conversion into the indazolin-3-ylidene-gold(I) complex 2 flanked by a pendent stibino functionalit…