3973023

Tellurium-based zinc ion transporters assisted by intramolecular chalcogen bonding

Date
March 20, 2024
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In the context of our ongoing exploration into the Lewis acidity of main group elements and their potential for ion transport applications, we have developed a series of antimony- and tellurium-based transporters. This presentation aims to delineate a unique class of electron-poor aryl telluride adorned with a flanking dipicolylamine (DPA) ligand. These novel compounds, characterized by the LP(N)→σ*(Te-C) chalcogen bond, have been evaluated for their capability to transport Zn2+ ions. UV-vis titration and NBO analyses demonstrate that the aforementioned chalcogen bond diminishes the DPA’s affinity for Zn2+ ions, thereby enhancing the likelihood of facile release. This inference finds support in U-tube Zn2+ transport assays, revealing a direct correlation between the strength of the LP(N)→σ*(Te-C) chalcogen bond and the efficiency of these compounds as zinc ion transporters. This assertion is further substantiated by results from S and Se analogs, which exhibit greater Zn2+ ion binding affinity as evidenced by their limited transport activity. Collectively, these findings underscore the utility of chalcogen bonding as a valuable tool for tailoring the properties of Zn2+ ion transporters.

Presenter

Speaker

Speaker Image for Francois Gabbai
Texas AM Univ

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