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3530446

Near IR photoluminescence of magic numbered gold clusters labeled with chromophores

Date
April 8, 2021

The study of gold nanoclusters is on the forefront of scientific research. Monolayer protected Au25 nanoclusters (MPCs) have extreme versatility and unique optical and electrochemical properties that differ from the bulk gold material. Gold nanoclusters exhibit characteristic superatom behavior; a unique property that allows the central gold cluster in each atom to transfer electrons to the ligand attached. They are magic number clusters and thus have increased stability due to their closed shell electron configuration. Gold nanoclusters display optimal optical absorption in the near-infrared region, and thus reduce toxicity when used in biological applications. Owing to their nanoscale size regime, their surface area-to-volume ratio increases exponentially thus allowing gold nanoclusters to be administered in low concentrations, with increased payload per kilogram. Due to their biocompatibility, quantum- sized gold nanoclusters are highly applicable as biochemical markers and even as drug delivery vehicles.
A limitation of these clusters is their low NIR fluorescence. Exchanging the core-stabilizing ligand with a fluorescent chromophore ligand allows for nanoclusters to be tailored to possess desired optical and electrochemical properties. This project focuses specifically on the modification of the surface of each gold nanocluster using chromophore ligands to make the nanocluster fluorescent. Using gold nanoclusters for the purpose of enhanced biological imaging offers a more accurate, and less invasive way to detect cancerous tumors.
With their plethora of biological applications, gold nanoclusters behold the capability to revolutionize the world of science. The details of the synthesis and characterization of enhanced fluorescent gold nanoclusters will be presented.

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