3827160

Evaluation of human serum albumin nanoparticles for encapsulation and delivery of near infrared ionic dyes with selective toxicity to cancer cells | Poster Board #317

Date
March 26, 2023

Nanoparticles have gained interest in drug delivery because their small size enables their uptake into most parts of the body and enhances permeability and retention effect in tumors. Protein nanoparticles from human serum albumin (HSA) are suitable for drug delivery due their biocompatibility. As a result, the HSA nanoparticles have been approved by the Food and Drug Administration for delivery of an anticancer drug, paclitaxel. This study explores the use of HSA nanoparticles for encapsulation and delivery of a near-infrared ionic dyes with IR 780 cation and various anions with potential therapeutic applications against cancer. IR 780 is a near-infrared dye which provides selective toxicity for tumor mitochondria and non-toxic to normal cells based on the anion. The results from this study shows that the dye in HSA particles can be delivered by using enzymes that are overexpressed in tumors, or by photothermal heating of the nanoparticles using a near infrared laser illumination. The dye emits light in the NIR wavelength region of the spectrum (also called the diagnostic window) which provides the additional advantage for tumor diagnosis.

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: [ANYL] Division of Analytical Chemistry
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: [ANYL] Division of Analytical Chemistry