3923961

Detection of copper (II) ions with a fluorescent "turn off" sensor in aqueous solutions

Date
August 16, 2023
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Copper ions are an essential nutrient and play a critical role in cellular physiology. This project investigated the potential applications of an acridinium based fluorescent dye as a “turn off” sensor for the detection and quantification of copper ions. In pure water, 10-methyl-9-phenylacridinium ions emit green fluorescent light at 510 nm. Upon the addition of poly(methacrylic acid) (PMAA), the emission of phenyl acridinium was enhanced by approximately three folds under acidic conditions. The emission of dye/PMAA mixture was strongest at around pH 5 when the solution was chilled in an ice-water bath. Addition of micromolar concentration range of Cu2+ ions significantly quenched the emission of dye/PMAA mixture. The sensor displayed excellent selectivity toward Cu2+ ions against eleven divalent or trivalent metal ions including Mg2+, Ca2+, Ba2+, Sr2+, Zn2+, Cd2+, Hg2+, Pb2+, Co2+, Ni2+, and Fe3+. The linear response range for Cu2+ ions is 1.0 to 10.0 μM. The detection mechanism is likely through photo-induced electron transfer that effectively quenches the emission of the acridinium derivative. The polymer plays a critical role by bringing the phenyl acridinium and Cu2+ ions close to each other which promotes the intermolecular photo-induced electron transfer.

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