3755743

Stability profiles of human growth hormone (HGH) and the interactions of HGH DNA

Date
August 21, 2022

Human Growth Hormone (HGH), secreted from the anterior pituitary gland in the brain during REM sleep, is vital to health as it stimulates growth and cell reproduction. HGH is highest in adolescence and declines with age. The present study analyzed the chemical structure, sequence, and interactions in the HGH DNA complex using molecular editing programs. Quantification of peptide and protein stability was studied before modeling the complex. The HGH molecule profile was assessed for thermodynamic stability and interactions by studying energy gaps, molecular orbitals, optimized energy, and polarization. The analysis also utilized open-source and commercial molecular editing programs equipped with an auto-optimization feature, which determines the theoretical values of a certain molecule’s atomic and physicochemical properties of the molecules through the orbital and Density Functional Theory (DFT).

Presenter

Speaker Image for Richard Kyung
Director, CRG-NJ

Related Products

Thumbnail for Functionalized biochemical nanoparticles for bio-imaging and molecular diagnostics of neurodegenerative diseases | Poster Board #701
Functionalized biochemical nanoparticles for bio-imaging and molecular diagnostics of neurodegenerative diseases | Poster Board #701
Nano-scaled photosensitizers for the treatment of neurodegenerative diseases are the focus of nanosciences, as their optical properties make them exciting candidates for applications in the medicinal field…
Thumbnail for Stereochemical analysis of porphyrins to control free radicals for the treatment of periodontal disease
Stereochemical analysis of porphyrins to control free radicals for the treatment of periodontal disease
The general aim of this paper was to study porphyrin molecules and derivatives for dental inflammation caused by oral bacteria, primarily the periodontal pathogens…
Thumbnail for Study on nanomaterials to reduce reactive oxygen species for the treatment of tumor cells
Study on nanomaterials to reduce reactive oxygen species for the treatment of tumor cells
This project examines tumor cell therapy using targeted nanoparticles, including metalloporphyrin derivatives. Limitless combinations of metals and porphyrins make the pharmaceutical properties of the compounds applicable to a variety of specific applications…