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3755743
Stability profiles of human growth hormone (HGH) and the interactions of HGH DNA
Date
August 21, 2022
Human Growth Hormone (HGH), secreted from the anterior pituitary gland in the brain during REM sleep, is vital to health as it stimulates growth and cell reproduction. HGH is highest in adolescence and declines with age. The present study analyzed the chemical structure, sequence, and interactions in the HGH DNA complex using molecular editing programs. Quantification of peptide and protein stability was studied before modeling the complex. The HGH molecule profile was assessed for thermodynamic stability and interactions by studying energy gaps, molecular orbitals, optimized energy, and polarization. The analysis also utilized open-source and commercial molecular editing programs equipped with an auto-optimization feature, which determines the theoretical values of a certain molecule’s atomic and physicochemical properties of the molecules through the orbital and Density Functional Theory (DFT).
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