4320639
Synthesis and fungicidal activity of novel 2,4-diaminoquinazolines as dihydrofolate reductase inhibitors
Date
August 19, 2025
Septoria tritici blotch (STB), caused by the fungal pathogen Zymoseptoria tritici, is one of the most damaging diseases of bread wheat. STB management relies heavily on fungicides. To both control the disease and mitigate resistance development of existing solutions, fungicides with novel target sites of action are in demand. A series of 2,4-diaminoquinazolines (DAQ) were identified as fungicide hits against STB with an uncommercialized fungicide target site, dihydrofolate reductase (DHFR). Details on the synthesis and attributes of these novel DAQs series will be reviewed.
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