The accreditors of this session require that you periodically check in to verify that you are still attentive.
Please click the button below to indicate that you are.
3925514
Studies in C-glycoside synthesis: from SN2-like displacement to cross coupling
Date
August 13, 2023
Explore related products in the following collection:
C-glycosides are hydrolytically stable analogs of glycans and glycoconjugates which in some cases have improved pharmacokinetic properties compared to their O-linked counterparts. While many approaches to specific C-glycosides have been described, general methods for C-linked disaccharide production are comparatively rare. This talk describes our labs studies directed to developing methods for C-linked disaccharide synthesis, including SN2 displacement of glycosyl sulfonates with carbon nucleophiles and light-free Ni-mediated cross-coupling reactions with redox active esters. The scope and limitations of these chemistries as well as the elaboration of the resulting products into C-linked disaccharides will be discussed.
The microbiome is host to trillions of commensal and pathogenic bacteria. These bacteria are recognized by peptidoglycan (PG) fragments that are shed as bacteria repair and maintain their cell wall…