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Our research program combines the tools and principles of chemistry with the molecules and processes of living cells to synthesize new molecules and molecular assemblies with novel physical, chemical and biological functions. Examples of this synergistic chemical/biological approach to synthesis will be discussed including (1) the addition of amino acids with novel biological, chemical and physical properties to the genetic codes of prokaryotic and eukaryotic organisms, (2) recapitulating the evolution of mitochondria in a synthetic eukaryotic system, and (3) characterizing organisms with chimeric RNA-DNA genomes.
Controlled radical polymerization (CRP) is widely used to prepare a broad range of polymeric materials for diverse applications in various fields. One of the most important characteristics of a CRP is maintaining high livingness throughout the polymerization…
There remains a need to develop novel SARS-CoV-2 therapeutic options that improve upon existing therapies by an increased robustness of response, fewer safety liabilities, and global-ready accessibility…