Explorations of a microwave-assisted synthesis of N,N-dialkyl-2,4-dinitroaniline: A nucleophilic aromatic substitution reaction as an undergraduate organic chemistry laboratory experiment | Poster Board #132

Studies on nucleophilic aromatic substitution reactions have been reported in scientific literature and practiced in undergraduate organic laboratory experiments. In this study we describe our efforts to develop a microwave-assisted synthesis of a nucleophilic aromatic substitution reaction that includes a wide variety of secondary alkylamines to react with 2,4-dinitrochlorobenzene. The scope of the reaction was explored and discussed. The experiment fits the sophomore organic chemistry lab well. It also allows the students to work and characterize their own unknown products with IR and 1H NMR spectroscopy.