Lysyl hydroxylase-2 (LH2) is a Fe(II)/alpha-ketoglutarate-dependent oxygenase superfamily member. This enzyme catalyzes the hydroxylation of lysine to hydroxylysine in collagen, which results in stable hydroxylysine aldehyde-derived collagen cross-links (HLCCs)…
Accurate modeling of conformational states and dynamics is critical for understanding the behavior and function of biomolecules. Polarizable force fields such as AMOEBA, can provide an accurate description of atomic interactions…