William Malachowski
Appearances
- SESSION: UNDERGRADUATE RESEARCH POSTERS: ORGANIC CHEMISTRY:
Presenter
Speakers
- DateMarch 20, 2022Recent research has shown that drug candidates with more all-carbon chiral centers are associated with an increase in solubility and complexity, which affords more selective interactions with target proteins…
Presenter
Speaker
- DateMarch 21, 2022Molecules with sp3 and chiral carbons have fewer indiscriminate interactions with other biomolecules, have better solubility properties, and increased selectivity, making them better drug candidates…
Presenter
Speaker
- DateMarch 23, 2022The Birch reduction-alkylation coupled to the desymmetrizing Mizoroki-Heck reaction is a novel synthetic tool to form fused tricyclic ring systems with a quaternary stereocenter from inexpensive and easily available starting materials…
Presenter
Speaker
- Through organic synthesis and medicinal chemistry experimentation, a primary goal is the development of new processes and tools that explore unknown areas of the chemical structure space for drug development…
Presenter
Speaker
- Through organic synthesis and medicinal chemistry experimentation, a primary goal is the development of new processes and tools that explore unknown areas of the chemical structure space for drug development…
Speakers
- : [CHED] Division of Chemical Education
Speakers
Florida Southern CollUSC UpstateAssociate Professor of Chemistry, UNC AshevilleHigh Point University, High Point University, High Point, NC, US, academicAssociate Professor of Chemistry, Tarleton State University - : [CHED] Division of Chemical Education
Speakers
University of Nevada, RenoUniversity of Notre DameAssociate Professor, Mississippi CollegeIndiana State UniversityNortheastern UnivMuhlenberg CollegeAssociate Professor of Chemistry, Rhodes CollegeHigh Point University, High Point University, High Point, NC, US, academicUniversity of TampaPostdoctoral Research and Teaching Fellow, UNC AshevilleAssistant Professor, Lafayette CollegeMelvin Druelinger, Ph.D.Professor of Chemistry, Colorado State Univ PuebloSalt Lake Community CollegeDenison UniversitySoutheast Missouri State UniversityAllison Hurley Predecki, Ph.D.Associate Professor of Chemistry and Biochemistry, Shippensburg University of PennsylvaniaAssociate Professor, Shippensburg UniversityNorthern Kentucky UniversityTrinity UniversityCollege of the Holy CrossProvidence CollegeDavidson CollegeUSC UpstateProfessor, Eastern Oregon UniversityMichael S. Leonard, Ph.D.Professor of Chemistry, Washington & Jefferson CollegeNaresh Gunaganti, Ph.D.Associate Research Scientist, Northeastern UniversityBaljinder Singh, PhDSenior Research Scientist, Northeastern University, BostonResearch Assistant Professor, Northeastern UniversityWhitworth UniversityProfessor, Penn State Berks - Through organic synthesis and medicinal chemistry experimentation, a primary goal is the development of new processes and tools that explore unknown areas of the chemical structure space for drug development…
Speakers
- : [CHED] Division of Chemical Education
Speakers
Florida Southern CollUSC UpstateAssociate Professor of Chemistry, UNC AshevilleHigh Point University, High Point University, High Point, NC, US, academicAssociate Professor of Chemistry, Tarleton State University - : [CHED] Division of Chemical Education
Speakers
University of Nevada, RenoUniversity of Notre DameAssociate Professor, Mississippi CollegeIndiana State UniversityNortheastern UnivMuhlenberg CollegeAssociate Professor of Chemistry, Rhodes CollegeHigh Point University, High Point University, High Point, NC, US, academicUniversity of TampaPostdoctoral Research and Teaching Fellow, UNC AshevilleAssistant Professor, Lafayette CollegeMelvin Druelinger, Ph.D.Professor of Chemistry, Colorado State Univ PuebloSalt Lake Community CollegeDenison UniversitySoutheast Missouri State UniversityAllison Hurley Predecki, Ph.D.Associate Professor of Chemistry and Biochemistry, Shippensburg University of PennsylvaniaAssociate Professor, Shippensburg UniversityNorthern Kentucky UniversityTrinity UniversityCollege of the Holy CrossProvidence CollegeDavidson CollegeUSC UpstateProfessor, Eastern Oregon UniversityMichael S. Leonard, Ph.D.Professor of Chemistry, Washington & Jefferson CollegeNaresh Gunaganti, Ph.D.Associate Research Scientist, Northeastern UniversityBaljinder Singh, PhDSenior Research Scientist, Northeastern University, BostonResearch Assistant Professor, Northeastern UniversityWhitworth UniversityProfessor, Penn State Berks - Through organic synthesis and medicinal chemistry experimentation, a primary goal is the development of new processes and tools that explore unknown areas of the chemical structure space for drug development…
Speakers
- : [CHED] Division of Chemical Education
Speakers
Florida Southern CollUSC UpstateAssociate Professor of Chemistry, UNC AshevilleHigh Point University, High Point University, High Point, NC, US, academicAssociate Professor of Chemistry, Tarleton State University - : [CHED] Division of Chemical Education
Speakers
University of Nevada, RenoUniversity of Notre DameAssociate Professor, Mississippi CollegeIndiana State UniversityNortheastern UnivMuhlenberg CollegeAssociate Professor of Chemistry, Rhodes CollegeHigh Point University, High Point University, High Point, NC, US, academicUniversity of TampaPostdoctoral Research and Teaching Fellow, UNC AshevilleAssistant Professor, Lafayette CollegeMelvin Druelinger, Ph.D.Professor of Chemistry, Colorado State Univ PuebloSalt Lake Community CollegeDenison UniversitySoutheast Missouri State UniversityAllison Hurley Predecki, Ph.D.Associate Professor of Chemistry and Biochemistry, Shippensburg University of PennsylvaniaAssociate Professor, Shippensburg UniversityNorthern Kentucky UniversityTrinity UniversityCollege of the Holy CrossProvidence CollegeDavidson CollegeUSC UpstateProfessor, Eastern Oregon UniversityMichael S. Leonard, Ph.D.Professor of Chemistry, Washington & Jefferson CollegeNaresh Gunaganti, Ph.D.Associate Research Scientist, Northeastern UniversityBaljinder Singh, PhDSenior Research Scientist, Northeastern University, BostonResearch Assistant Professor, Northeastern UniversityWhitworth UniversityProfessor, Penn State Berks - DateMarch 26, 2023Through organic synthesis and medicinal chemistry experimentation, a primary goal is the development of new processes and tools that explore unknown areas of the chemical structure space for drug development…
Presenter
Speaker
- DateMarch 27, 2023Studies show that currently, there are many drug candidates that have flat, aromatic structures with a high proportion of sp2 carbons. However, in fact, drug candidates with more chiral centers and sp3 carbons are more successful in clinical trials…
Presenter
Speaker
- DateMarch 27, 2023The Malachowski group has previously focused on synthesizing phenanthridinone analogs with more chiral centers and sp3 carbons, developing the Birch-Heck reaction sequence as an efficient tool to generate these molecules…
Presenter
Speaker
- DateMarch 18, 2024Recent structural studies of drug candidates have shown that molecules with more tetrahedral, sp3 centers, including chiral ones, are more likely to succeed in clinical trials and eventually become successful drugs…
Presenter
Speaker
- DateMarch 18, 2024Oseltamivir is an antiviral prodrug used in the prevention and treatment of influenza. It is a small molecule, consisting of a cyclohexene ring with four attached groups, including an amino group…
Presenter
Speaker
- DateMarch 18, 2024This research aimed to create complex nitrogen-containing drug intermediates via a process adapted from the Birch-Heck synthesis…
Presenter
Speaker
- DateMarch 17, 2024Quaternary carbon centers are an important motif for a large number of natural products. Unfortunately, the creation of this motif poses a great challenge given its sterically hindered nature. This work focuses on forming quaternary carbon centers through two different methods…
Presenter
Speaker
- DateMarch 24, 2025Heterocycles, especially those containing nitrogen, are structures commonly found in pharmaceuticals; therefore, developing efficient and selective synthetic pathways to generate them is crucial…
Presenter
Co-Author
