Recent research has shown that drug candidates with more all-carbon chiral centers are associated with an increase in solubility and complexity, which affords more selective interactions with target proteins…
Molecules with sp3 and chiral carbons have fewer indiscriminate interactions with other biomolecules, have better solubility properties, and increased selectivity, making them better drug candidates…
The Birch reduction-alkylation coupled to the desymmetrizing Mizoroki-Heck reaction is a novel synthetic tool to form fused tricyclic ring systems with a quaternary stereocenter from inexpensive and easily available starting materials…
Through organic synthesis and medicinal chemistry experimentation, a primary goal is the development of new processes and tools that explore unknown areas of the chemical structure space for drug development…
Through organic synthesis and medicinal chemistry experimentation, a primary goal is the development of new processes and tools that explore unknown areas of the chemical structure space for drug development…
Through organic synthesis and medicinal chemistry experimentation, a primary goal is the development of new processes and tools that explore unknown areas of the chemical structure space for drug development…
Through organic synthesis and medicinal chemistry experimentation, a primary goal is the development of new processes and tools that explore unknown areas of the chemical structure space for drug development…
Through organic synthesis and medicinal chemistry experimentation, a primary goal is the development of new processes and tools that explore unknown areas of the chemical structure space for drug development…
Studies show that currently, there are many drug candidates that have flat, aromatic structures with a high proportion of sp2 carbons. However, in fact, drug candidates with more chiral centers and sp3 carbons are more successful in clinical trials…
The Malachowski group has previously focused on synthesizing phenanthridinone analogs with more chiral centers and sp3 carbons, developing the Birch-Heck reaction sequence as an efficient tool to generate these molecules…
Recent structural studies of drug candidates have shown that molecules with more tetrahedral, sp3 centers, including chiral ones, are more likely to succeed in clinical trials and eventually become successful drugs…
Oseltamivir is an antiviral prodrug used in the prevention and treatment of influenza. It is a small molecule, consisting of a cyclohexene ring with four attached groups, including an amino group…
Quaternary carbon centers are an important motif for a large number of natural products. Unfortunately, the creation of this motif poses a great challenge given its sterically hindered nature. This work focuses on forming quaternary carbon centers through two different methods…
Heterocycles, especially those containing nitrogen, are structures commonly found in pharmaceuticals; therefore, developing efficient and selective synthetic pathways to generate them is crucial…