Wei-Tse Hsu

Currently, I'm a chemical engineering Ph.D. student in the Shirts group at University of Colorado, Boulder, with a general interest in computational science and bioengineering. My research interests lie in the applications of various computational methodologies to the exploration of the configurational space of flexible biomolecular systems, such as protein-peptide binding and protein-nucleic acid binding. To improve the interoperability of the methods, I am also working on SCALE-MS, which is an NSF-funded project to develop an extensible framework to support adaptive and asynchronous executions of multiple kinds of advanced sampling methods. With these promising methods, I am aiming to gain more insights into biophysical properties of a wide array of binding complexes, including their binding affinity, binding ensembles, structural plasticity, binding mechanisms, or multimodal specificity.