Theresa Reineke

Cationic polymers are versatile alternatives to engineered viruses for the delivery of genome editing payloads. Yet, their clinical translation hinges on facile exploration of broad chemical design spaces and deriving structure-function relationships governing performance…

Oral drug delivery is the most common form of medication administration worldwide. However, very few small molecule therapeutics can be successfully formulated for oral administration without the use of polymer additives called excipients…

The field of gene therapy, which aims to treat patients by modulating gene expression, has come to fruition and has landed several landmark FDA approvals…

There are a variety of small molecule toxins found in crops that can be extremely carcinogenic to humans, posing dangerous hazards in food production and consumption. This work exploits polymers, with commercially available monomers, as capture agents for various toxins such as mycotoxins…

There are a variety of small molecule toxins found in crops that can be extremely carcinogenic to humans, posing dangerous hazards in food production and consumption. This work exploits polymers, with commercially available monomers, as capture agents for various toxins such as mycotoxins…

Cationic polymer vehicles continue to gain promise for nucleic acid delivery as a result of their scalability, biocompatability, and chemical versatility…

Poly(_N_-isopropylacrylamide-stat-_N,N_-dimethylacrylamide) (PND) bottlebrush copolymer excipients have recently been shown to have great potential as unimolecular vehicles for the non-covalent sequestration and solubilization of model small-molecule therapeutics…

Nature offers a wide selection of biobased molecules, many of which have similar chemical structures with only slight differences in the types of substituents present. However, such slight differences may significantly impact the physical properties of the resulting polymers…

Cationic polymer vehicles have emerged as promising platforms for nucleic acid delivery owing to their scalability, biocompatibility, and chemical versatility…

Polymer excipients are inactive ingredients included in pharmaceutical formulations that sequester and stabilize small molecules and larger payloads through non-covalent interactions with active pharmaceutical ingredients (APIs), proteins, and polynucelotides…

Bottlebrush polymers have great potential as vehicles to noncovalently sequester, stabilize, and deliver active pharmaceutical ingredients for oral drug delivery…

Cationic polymer vehicles have emerged as promising platforms for nucleic acid delivery because of their scalability, biocompatibility, and chemical versatility…

The incorporation of renewable feedstocks into polymer backbones is of great importance in modern polymer science. We report the synthesis of 1,3-diyne polymers derived from the bispropargyl ethers of isosorbide, isomannide, and isoidide…

The field of nucleic acid therapeutics, which aims to treat patients by modulating gene expression, has come to fruition, and has landed several landmark FDA approvals. Cationic polymers are tailorable alternatives to engineered lipids and viruses for the delivery of nucleic acid payloads…

This work focuses on leveraging linear polymer affinity agents and surface-enhanced Raman scattering (SERS) for the detection of food contaminants…

Multifunctional macromolecules have a tremendous impact on a multitude of applications…

Additive manufacturing, also known as 3D printing, is increasingly moving from prototyping to production. Accordingly, the amount of 3D printed waste is also increasing…

The importance of genetic therapeutics and vaccines was highlighted by the new mRNA-based SARS-CoV-2 vaccines. Nucleic acids can also be used to treat many other important diseases such as genetic diseases and cancer…

Levoglucosan is a bicyclic acetal obtained from the pyrolysis of cellulosic biomass at a projected price point of $1.33 to $3.0/kg, which is competitive with many petroleum-derived monomers…

Engineering therapeutic delivery vehicles via exploration of novel polycation moieties and topologies hinges on the development of facile synthesis and assembly methods…

Engineering therapeutic delivery vehicles via exploration of novel polycation moieties and topologies hinges on the development of facile synthesis and assembly methods…

Cellulose, a highly abundant polymeric material, is difficult to chemically modify due to its poor solubility. In industry, a common approach to derivatize cellulose is to use heterogeneous slurry conditions, consisting of an organic/water solvent system with caustic for cellulose swelling…

Glycolipids are ubiquitous in nature, mostly found in the cell membranes of living systems. The structure of the liquid crystalline state of the glycolipids plays a pivotal role in various biological functions…

Quinine is a promising natural product building block for polymer-based nucleic acid delivery vehicles as its structure enables DNA binding through both intercalation and electrostatic interactions…

DIVISION/COMMITTEE: [PMSE] Division of Polymeric Materials Science and Engineering

Antisense oligonucleotides (ASOs) are a promising class of gene therapeutics because of their enhance stability, ease of manufacturing, small size, and ease of shuttling between the cellular cytosol and nucleus…

DIVISION/COMMITTEE: [PMSE] Division of Polymeric Materials Science and Engineering

Cellulose ethers are commonly used as viscosity modifiers in aqueous applications ranging from personal care and food products to paints and construction materials…

Thermoset network materials have tremendous utility due to their thermal stability and mechanical properties. However, many materials are made using petroleum-derived monomers and are incompatible with recycling or degradation at the end of their use cycle…

Natural products offer modern polymer chemistry and engineering numerous pathways for tailorable materials development. Renewable feedstocks provide a multitude of rich monomer functionality (i.e…

Nucleic acids are important therapeutics yet issues with delivery efficiency continue to hinder widespread advancement in the clinic. Delivery systems are crucial to encapsulate and protect these large and highly sensitive payloads and improve tissue internalization ensuring efficacy…

Nucleic acid delivery with cationic polymers is a promising alternative to expensive viral-based methods; however, it often suffers from lower performance and high cytotoxicity…

Thionolactones remain understudied in the sustainable polymer field despite their susceptibility to rROP…

In the past decade, gene therapy and in particular use of nucleic acids as active therapeutic ingredients has made major strides. One of the major bottlenecks in developing successful therapies is the efficient delivery of nucleic acids in the target cells of the patients…

Cationic polymers are promising for delivery of nucleic acids, yet, the development of high-performance vehicles is challenged by an infinite synthetic design space…

One of the major challenges in gene therapy development is the successful delivery of genes in various forms such as DNA, RNA, etc., (also referred to as nucleic acids) into the diseased cells of the patients…

Cationic polymers offer an alternative to viral vectors in nucleic acid delivery. However, the development of polymer vehicles capable of high transfection efficiency and minimal toxicity has remained elusive and continued exploration of the infinite design space is required…

Many oral active pharmaceutical ingredients (APIs) are limited by their poor aqueous solubility in the gastrointestinal tract…

Nucleic acid delivery with cationic polymers is a promising alternative to expensive viral-based methods; however, it often suffers from lower performance. Herein, we present a highly efficient delivery system based on cinchona alkaloid natural products copolymerized with 2-hydroxyethyl acrylate…

Bottlebrush polymers are important nanomolecular architectures that can form nanodroplets with active pharmaceutical ingredients (API) in amorphous solid dispersions (ASDs)…

DIVISION/COMMITTEE: [PMSE] Division of Polymeric Materials Science and Engineering

Virus detection is highly important; the last several years, since the onset of the SARS-CoV-2 pandemic, have highlighted a weakness in the field: the need for highly specialized and complex methodology for sensitive virus detection, which also manifests as sacrifices in limits of detection made to…

Cationic polymers are promising for delivery of nucleic acids, yet, the development of high-performance vehicles is challenged by an infinite synthetic design space…

The facile synthesis of a polymer library with systematic variations in length, binary composition, p_K_a, and hydrophobicity has been synthesized to optimize intracellular pDNA and CRISPR-Cas9 delivery performance…

Mesenchymal stem cell (MSC) treatments are promising for cellular therapy and tissue regeneration for their abilities to self-renew and differentiate…

Our group has demonstrated that various polymer structures are promising for functional delivery of nucleic acids. In particular, quinine-based polymers show high transfection efficiency, which stems from the electrostatic as well as the non-electrostatic means of binding with pDNA…

Engineering therapeutic delivery vehicles via exploration of novel polycation moieties and topologies is a promising avenue to improve biological performance, which hinges on the development of facile synthetic methods…

DIVISION/COMMITTEE: [PMSE: Division of Polymeric Materials Science and Engineering]

Reactive compatibilizers are an attractive solution to address the problem of recycling mixed plastic waste…