Session: Undergraduate Research Posters: Organic Chemistry:

Phosphorus and sulfur based heterocycles display potent biological activity and as such have become important synthetic targets. We have developed a synthetic route towards a novel seven-membered heterocycle containing a distinctive sulfur-phosphorus-nitrogen bond, named a thiol phonsphonamidate. Our synthetic methodology allows for diversification of the heterocycle utilizing different amino acid starting materials and a key ring-closing metathesis step. Herein, we report progress towards the formation of a library of compounds featuring the heterocycle diversified at various positions. The eventual completion of a large library of diversified compounds will allow for investigations into the biological utility of the novel heterocycle.

Stephen Sieck

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