Strained-three membered rings are important synthons in modern organic chemistry. 1,10-Phenanthroline (phen) supported copper(II) systems have shown a long history of supporting cyclopropanation reactions by activating diazo carbonyl compounds for reactions with olefins…
Copper(II) pyridyl-based ligands with triflate counterions were utilized in modified Chan-Evans-Lam cross-coupling through _N_-arylation of multifarious _N_-nucleophiles and aryl boronic acids…
Human carbonic anhydrase II (hCAII) is a zinc metalloenzyme directly involved with catalyzing the reversible hydration of carbon dioxide into bicarbonate and hydrogen ions…
Human carbonic anhydrase II (HCA2) was recently reported to catalyze the asymmetric reduction of ketones using PhSiH3. Here we follow up on this chemistry by measuring a wealth of steady-state kinetics for this process…
Copper(II) pyridyl-based ligands with triflate counterions were utilized in modified Chan-Evans-Lam cross-coupling through _N_-arylation of multifarious _N_-nucleophiles and aryl boronic acids…
The development of chiral alcohols through the reduction of ketones is industrially relevant due to the prevalence of chiral alcohols as starting materials in pharmaceuticals and industrial technologies. To further advance these ketone reductions, novel and sustainable methods must be established…
One of the most efficient mechanisms for creating carbon-carbon bonds in organic synthesis is the Michael (conjugate) addition reaction. Over the years, Lewis acid catalysts have shown significant improvements in both reaction time and yield for this process…
Cu2+-based synthetic architectures have been well-studied to catalyze redox-neutral carbene transfer reactions between different diazo carbonyl compounds (carbene source) and heteroaryl coupling partners for _N_-H/_O_-H insertion reactions…