The Biginelli cyclocondensation is a multicomponent reaction to synthesize dihydropyrimidines by utilizing ethyl acetoacetate, thiourea, and an aryl aldehyde under acidic conditions…
Natural products and their analogs have been sources of inspiration for the discovery and development of therapeutically relevant small molecules since the beginning of human civilization…
Benchtop nuclear magnetic resonance (NMR) spectroscopy has enabled the monitoring and optimization of chemical transformations while simultaneously providing kinetic, mechanistic, and structural insight into reaction pathways with quantitative precision…