Dr. Neil L. Kelleher

Native mass spectrometry (nMS) is a rapidly growing field for the characterization of large proteins and protein complexes, preserving endogenous (“native”) non-covalent interactions…

Neil L. Kelleher, PhD is the Walter and Mary Glass Professor of Life Sciences and professor of chemistry at Northwestern University. He also directs the Proteomics Center of Excellence and a member of the Robert H. Lurie Comprehensive Cancer Center at Northwestern…

Bacteria and fungi offer many new compounds yet to be discovered and exploited as leads in crop protection and drug discovery campaigns. The genomics era has ushered in a wealth of information about the natural product biosynthetic arsenals of both, promising vast new collections of fine chemicals…

Proteoforms are the key effectors in human health and disease. Understanding proteoform distributions in human tissues is critical to pathogenic studies and therapeutics. Imaging mass spectrometry (IMS) is a powerful technique for mapping proteins in tissues…

Spatially-resolved chemical profiling of substructures in biological tissues has attracted great attention. The abundance of proteins as the effector molecules plays an important role in the biological functions that vary across tissue space…

Spatially-resolved chemical profiling of substructures in biological tissues has attracted great attention. The abundance of proteins as the effector molecules plays an important role in the biological functions that vary across tissue space…

: [ANYL] Division of Analytical Chemistry

Spatially-resolved chemical profiling of substructures in biological tissues has attracted great attention. The abundance of proteins as the effector molecules plays an important role in the biological functions that vary across tissue space…

: [ANYL] Division of Analytical Chemistry

Spatially-resolved chemical profiling of substructures in biological tissues has attracted great attention. The abundance of proteins as the effector molecules plays an important role in the biological functions that vary across tissue space…

: [ANYL] Division of Analytical Chemistry

Spatially-resolved chemical profiling of substructures in biological tissues has attracted great attention. The abundance of proteins as the effector molecules plays an important role in the biological functions that vary across tissue space…

: [ANYL] Division of Analytical Chemistry

Spatially-resolved chemical profiling of substructures in biological tissues has attracted great attention. The abundance of proteins as the effector molecules plays an important role in the biological functions that vary across tissue space…

Post-translational modifications (PTM) affect protein structure, activity, transport and function. The presence of PTMs and their dynamic response to conditions dramatically increases the complexity and versatility of the proteome beyond what can be predicted based on the known protein-coding genes…