Dr Natalia Tretyakova
Professor, University of Minnesota
Appearances
SESSION: CURRENT TOPICS IN BIOLOGICAL CHEMISTRY:Presenter
Graduate Student, University of MinnesotaSpeakers
Graduate Student, University of MinnesotaProfessor, University of Minnesota
DateJuly 8, 2021Division/Committee: [TOXI] Division of Chemical ToxicologyOrganizers
Professor, University of MinnesotaDirector- DateAugust 23, 20211,3-butadiene (BD) is a known human carcinogen found in the polymer industry, tobacco smoke, and urban air. BD is metabolically activated to electrophilic metabolite, 3,4-epoxy-1-butene (EB)…
Presenter
Speakers
Professor, University of Minnesota 
DateAugust 22, 2021DNA-protein crosslinks (DPCs) are exceptionally bulky, structurally diverse DNA adducts formed in cells endogenously and upon exposure to _bis_-electrophiles, reactive oxygen species, and ionizing radiation…Presenter
Professor, University of Minnesota- DateAugust 22, 2021Division/Committee: [TOXI] Division of Chemical Toxicology
Organizers
DirectorProfessor, University of MinnesotaPresider
Professor, University of Minnesota 
DateAugust 23, 2021In all living systems, genetic information is encoded by a simple chemical code of four major nucleotide bases (A, T, G, and C). However, up to 2% of the nucleobases in our genome are not in their canonical form, but are instead structurally altered…Presenter
Professor, University of Minnesota
DateAugust 22, 20211,3-butadiene (BD) is a known human carcinogen found in the polymer industry, tobacco smoke, and urban air. BD is metabolically activated to electrophilic metabolite, 3,4-epoxy-1-butene (EB)…Presenter
Speakers
Professor, University of Minnesota- DateAugust 21, 2022DNA methylation status is an important epigenetic regulator of gene expression, cell identity, and cellular function. Cells are equipped with various enzymes to carefully introduce and erase DNA methylation marks across the genome…
Presenter
Speakers
Graduate Student, University of MinnesotaProfessor, University of Minnesota - DateAugust 21, 2022DNA methylation status is an important epigenetic regulator of gene expression, cell identity, and cellular function. Cells are equipped with various enzymes to carefully write and erase DNA methyl marks across the genome…
Presenter
Graduate Student, University of MinnesotaSpeakers
Professor, University of Minnesota - DateAugust 21, 2022Division/Committee: [TOXI] Division of Chemical Toxicology
Organizer
Professor, Baylor UniversityOrganizer, Presider
The University of Arizona College of PharmacyPresiders
Professor, University of MinnesotaProfessor, ETH Zurich - DateAugust 23, 2022Protein glycation is a disease associated, non-enzymatic, posttranslational modification generated by endogenous dicarbonyl metabolites. One example from this class of compounds is methylglyoxal (MGO). MGO is a carbohydrate-derived metabolite naturally produced in living cells…
Presenter
Graduate Student, University of MinnesotaSpeakers
Graduate Student, University of MinnesotaProfessor, University of Minnesota - DateAugust 23, 2022DNA-protein crosslinks (DPCs) form when proteins become covalently trapped on DNA in the presence of _bis_-electrophiles and free radical species. These highly cytotoxic lesions obstruct DNA replication and block gene expression…
Presenter
University of Minnesota Twin CitiesSpeaker
Professor, University of Minnesota - DateAugust 23, 2022Due to its long half-life and high concentrations in human blood, hemoglobin is a useful reservoir of protein-electrophile adducts, serving as a record of a patient’s long-term exposures…
Presenter
Speakers
Professor, University of Minnesota - DateAugust 21, 2022Division/Committee: [TOXI] Division of Chemical Toxicology
Organizer
Professor, Baylor UniversityOrganizer, Presiders
University of ToledoDistinguished Professor, University of UtahPresider
Professor, University of Minnesota - DateAugust 21, 20225-Methylcytosine (5-mC) is a key epigenetic mark that controls the levels of gene expression, establishes cell identity, and regulates cellular function…
Presenter
Professor, University of Minnesota - DateAugust 14, 2023Enzymatic methylation at C-5 position of cytosine (5mC) is a hallmark of mammalian epigenetic programming and is critical in regulating gene expression…
Presenter
Speakers
- DateAugust 13, 20231,3-butadiene (BD) is a human carcinogen that is abundantly found in cigarette smoke, automobile exhaust, and some industrial settings. Exposure to BD leads to the blood disorders leukemia and lymphoma, along with cancers of the liver, lungs, mammary glands, and ovaries…
Presenter
Speakers
Professor, University of Minnesota - DateAugust 15, 2023Methylglyoxal (MGO) is an electrophilic byproduct of cellular metabolism and capable of reacting with nucleophilic biomolecules to form covalent adducts…
Presenter
University of Minnesota Twin CitiesSpeakers
Graduate Student, University of MinnesotaProfessor, University of Minnesota - DateAugust 15, 20231,3-Butadiene(BD) is a ubiquitous environmental mutagen and a known human carcinogen. BD can be bio-activated by cytochrome P450 monooxygenases to form mutagenic epoxide metabolites including the strongly genotoxic diepoxide, 2,3,4-diepoxybutane (DEB)…
Presenter
Speakers
Professor, University of Minnesota - DateAugust 15, 2023Smokers are exposed to thousands of chemicals present in cigarette smoke, including at least 70 known carcinogens, procarcinogens, and inflammatory agents. These molecules and their metabolites can directly damage cellular proteins and DNA leading to toxicity and mutations…
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Speakers
Graduate Student, University of MinnesotaProfessor, University of Minnesota - DateMarch 17, 2024Butadiene (BD) is a carcinogen typically found in cigarette smoke, automobile exhaust, and industrial settings. Exposure to BD can lead to various health complications including lung cancer when activated by cytochrome P450 monooxygenases to form 1,2,3,4–diepoxybutane (DEB)…
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Speakers
- DateAugust 19, 2024DNA and protein adducts are formed when electrophilic compounds an oxidants react with nucleophilic sites in cellular biomolecules. The formation of covalent adducts with proteins and DNA is associated with increased risk for cancer and other chronic diseases…
Presenter
Professor, University of Minnesota - DateAugust 20, 2024DNA-protein cross-links (DPCs) are formed following exposure to radiation, free radicals, and many exogenous agents. DPCs are deleterious to cells due to their effects on replication and transcription…
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Speakers
Professor, University of Minnesota - DateAugust 20, 2024N6-methyldeoxyadenosine (N6medA) is a recently discovered DNA mark which is dynamically regulated in the mouse brain following environmental stress and plays a role in the formation of fear extinction memories, immune response, and in neuroblastoma…
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Speakers
Professor, University of Minnesota - DateAugust 20, 2024Exposure to inflammatory and carcinogenic chemicals present in cigarette smoke and their metabolites results in damage to cellular proteins and DNA. The environment and other lifestyle factors (diet, sedentariness, stress etc…
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Speakers
Graduate Student, University of MinnesotaProfessor, University of Minnesota - DateAugust 20, 2024DNA-peptide crosslinks (DpCs) are produced via proteolytic cleavage of DNA-protein crosslink which can be formed endogenously when epigenetic mark 5-formylcytosine (5fC) in DNA reacts with lysine or arginine residents on the protein to form Schiff base conjugates…
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Speaker
Professor, University of Minnesota
