Insulin _Wakayama _is a clinically observed insulin variant where the conserved A3Val is replaced with a Leu and has 140-500-fold worse binding to the insulin receptor (IR) relative to native insulin. This severe impact on binding from such a subtle modification has puzzled researchers for decades…
Insulin _Wakayama_, a clinically observed insulin variant where the conserved Valine at the third residue on insulin’s A chain (ValA3) is replaced with a Leucine (Leu), displays a 140-to-500-fold worse binding to the insulin receptor (IR) compared to native insulin…