Milan Mrksich

In this work, a new class of antibody mimics was evaluated; specifically, the ‘megamolecule’ platform developed in our laboratory, where synthesized ligands react with recombinantly expressed fusion proteins to create multi-component, complex architectures…

DIVISION/COMMITTEE: [MPPG] Multidisciplinary Program Planning Group

DIVISION/COMMITTEE: [MPPG] Multidisciplinary Program Planning Group

Chromophores that can efficiently form the triplet state upon photoexcitation are essential for photocatalysis, triplet-triplet annihilation photon upconversion (TTA-PUC), and photodynamic therapy (PDT)…

Despite notable progress in automation and machine learning, traditional techniques for materials synthesis and testing continue to be inefficient, hindering the experimental validation and discovery process…

The development of protein-based materials with customizable properties is critical for applications in biotechnology and materials science. This work describes the design of metal-mediated protein assemblies by incorporating bipyridine-alanine (bpy) into tetracutinase as a building block…

This work describes the use of molecular dynamics strategies to design megamolecule building blocks for self-assembly networks…

This talk will describe an approach for synthesizing molecules that have sizes greater than 100 nm and yet are structurally perfectly defined. The approach relies on the selective and covalent reaction of an enzyme domain with an irreversible linker…

Despite the clinical success of antibody-drug conjugates (ADCs) in cancer therapy, current production methods struggle to deliver precisely defined drug loading and multi-targeting capabilities. We address these critical limitations through the megamolecule platform…