Matthew Tirrell

Division/Committee: [COLL] Division of Colloid & Surface Chemistry

Division/Committee: [COLL] Division of Colloid & Surface Chemistry

Division/Committee: [COLL] Division of Colloid & Surface Chemistry

Division/Committee: [COLL] Division of Colloid & Surface Chemistry

Division/Committee: [COLL] Division of Colloid & Surface Chemistry

Division/Committee: [COLL] Division of Colloid & Surface Chemistry

Division/Committee: [COLL] Division of Colloid & Surface Chemistry

Division/Committee: [COLL] Division of Colloid & Surface Chemistry

Protein-protein interactions (PPIs) dictate most biological processes, including those responsible for carcinogenesis. Targeted therapeutics acting on these oncogenic PPIs have naturally become the focus of novel drug discovery…

Division/Committee: [COLL] Division of Colloid & Surface Chemistry

Molecular engineering in our parlance means building functional systems from the molecular level up. Ten years ago, the University of Chicago launched what has now become the first school embracing and advancing this approach to applied science and engineering…

While there have been recent advances in designing soft materials to perform intriguing functions, there remains a dearth of materials that can molecularly recognize, capture, release, and collect targeted nutrients or contaminants to recycle on the nano-scale…

Polyelectrolyte complexation is increasingly recognized as a route to new materials, as a new tool for self-assembly, and as a frequent player in biological structures from the cellualr to the organismal level…

Cationic polypeptides readily complex with nucleic acids. As cationic polypeptide blocks conjugated with neutral water-soluble polymers, such as polyethylene oxide (PEG), they readily assemble into complex core micelles with nucleic acids…

Vascular disease is a leading cause of human morbidity and mortality and current therapies mainly address systemic risk factors but do not target the diseased vasculature directly…

Nature exploits all available covalent and non-covalent interactions for unparalleled spatiotemporal control over hierarchical length scales of macromolecular and supramolecular structure…

Nature exploits all available covalent and non-covalent interactions for unparalleled spatiotemporal control over hierarchical length scales of macromolecular and supramolecular structure…

Polyelectrolyte complexes (PECs) spontaneously assemble when solutions of oppositely charged polymers are mixed to form hydrated polymer-rich materials with promising properties for applications such as tissue engineering, water remediation and drug delivery…

Zwitterionic polymers have been widely promoted as effective antifouling agents due to the often-observed resilience of surfaces modified with zwitterionic moieties to the adhesion of proteins and microbial organisms…

Protein-protein interactions (PPIs) dictate most biological processes, including those responsible for carcinogenesis. Targeted therapeutics acting on these oncogenic PPIs have naturally become the focus of novel drug discovery…

Developing effective non-viral methods for delivery of nucleic acids and other macromolecular therapeutics is one of the most pressing challenges in nanomedicine…

Polyelectrolyte complex coacervation is an important process in nature and, in combination with synthetic variations in macromolecular architecture, provides new tools and versatility in the design of functional materials…

Polyelectrolyte complexes (PECs) are polymer rich phases which spontaneously form upon mixing oppositely charged polyelectrolytes in solution. The vast library of charged polymers that can associate into PECs provide a wide variety of potential chemical and physical properties…

A systematic investigation of the influence of sequence charge pattern on the secondary structure preferences of peptide-based polyampholytes and their responsiveness to external stimuli will be presented…

[HYBRID SESSION] The Dreyfus Prize in the Chemical Sciences is the highest honor of the Camille and Henry Dreyfus Foundation. Initiated in 2009, the prize has recognized some of chemistry's most accomplished and respected scientists…

Non-equilibrium states are prevalent in soft materials, necessitating a systematic approach for improved predictability and broader applications…

Zwitterionic polymers have shown great promise for a wide range of applications, including ion-separation membranes in water purification devices…

Single-use packaging contributes the largest fraction to global plastic waste pollution and is mainly recycled through mechanical methods, which result in shorter polymer chains that on their own cannot be reused to form new plastics…

Polyelectrolyte complex coacervation is an associative liquid-liquid phase separation process in systems of oppositely charged polyelectrolytes driven by concomitant entropic processes of water reorganization and counterion release…

Of the more than 260 million tons of plastic waste generated annually, packaging materials are the largest contributor due to the growth of single-use plastics and recycled at the lowest rate…

Atherosclerosis is the narrowing or hardening of arteries ascribed to the buildup of fatty plaque in the inner lining of arteries and remains the leading cause of morbidity and mortality in the United States and globally…

Membraneless coacervate microdroplets have long been proposed as model protocells as they can grow, divide, and concentrate RNA by natural partitioning…