Session: Undergraduate Research Posters: Medicinal Chemistry:

The aim of this study is to determine the compatibility of simvastatin (Zocor) in 1:1 binary mixtures with five pharmaceutical excipients: croscarmellose, pre-gelatinzed starch, microcrystalline cellulose 101, microcrystalline cellulose 102, and lactose monohydrate. Through the use of differential scanning calorimetry and thermogravimetric analysis, the study analyzes how the excipients affect the thermal stability of the active pharmaceutical ingredient, simvastatin. The differential scanning calorimetry and thermogravimetric analysis curves confirmed interactions between each of the following excipients and simvastatin: croscarmellose, pre-gelatinized starch, microcrystalline cellulose 101, and microcrystalline cellulose 102. These interactions lead to an overall decrease in the thermal stability of simvastatin.

Maria Ballester

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