Justin Wilson

Hydrogen sulfide (H2S) has been identified as a third gasotransmitter, joining carbon monoxide and nitric oxide in this role. The currently identified biological functions of H2S are diverse, ranging from vasodilation to inflammation…

Hydrogen sulfide (H2S) is an endogenous gasotransmitter with untapped potential as a therapeutic in the treatment of various diseases and disorders, such as ischemia-reperfusion injury as a result of myocardial infarction or stroke…

The use of radioactive metal ions for both therapeutic and diagnostic applications has led to significant advances in the field of nuclear medicine…

High-energy alpha particles emitted by the decay of radioactive isotopes demonstrate great promise for the treatment of cancer. Among the few α-emitting isotopes that possess radiological properties suitable for therapeutic use, Ac-225 and Ra-223 have shown remarkable efficacy in clinical studies…

Lanthanide-based luminescence represents an attractive alternative to conventional organic chromophores used for optical imaging applications…

Hydrogen sulfide (H2S) is an endogenously produced gasotransmitter with untapped potential as a therapeutic in the treatment of various diseases and disorders, such as ischemia-reperfusion injury as a result of trauma from heart attack or stroke…

Porous materials such as metal-organic frameworks (MOFs), which are constructed from organic linkers and inorganic nodes, have myriad potential applications in chemical separations, gas storage, and sensing…

Division/Committee: [INOR] Division of Inorganic Chemistry

Division/Committee: [INOR] Division of Inorganic Chemistry

Division/Committee: [INOR] Division of Inorganic Chemistry

A variety of metal ions that span the entirety of the periodic table have potential applications in nuclear medicine…

Division/Committee: [INOR] Division of Inorganic Chemistry

Division/Committee: [INOR] Division of Inorganic Chemistry

Hydrogen sulfide (H2S) is an endogenously produced gasotransmitter with untapped potential as a therapeutic in the treatment of various diseases and disorders, such as Parkinson's disease, inflammation, cancer, and ischemia-reperfusion injury…

Radium-223 (Ra-223) is the first and only alpha particle-emitting radioisotope approved for therapeutic use. It is indicated for the treatment of bone metastases in men with prostate cancer…

The manipulation of both endogenous and exogenous metal ions within biological systems provides an opportunity to develop new diagnostic and therapeutic drug candidates. By tuning the properties of these metal ions with careful ligand design strategies, these objectives can be achieved…

Hydrogen sulfide (H2S) is a gasotransmitter with important physiological functions in long-term potentiation and the mediation of oxidative stress. However, unlocking its therapeutic potential is challenging because it is also a toxic, flammable gas…

In this talk, efforts to develop chelators that are valuable the coordination of the heavy main group and f-block elements under aqueous conditions are described…

Inhibitors of the mitochondrial calcium uniporter (MCU) are valuable tools for studying the role of mitochondrial Ca2+ in various pathophysiological conditions. In this study, a ruthenium-based fluorogenic MCU inhibitor is presented…

The mitochondrial calcium uniporter (MCU), a transmembrane protein residing on the mitochondrial inner membrane, traffics calcium ions (Ca2+) into the mitochondrial matrix and is crucial in the maintenance of cellular function…

In this talk, efforts to develop chelators that are valuable the coordination of the heavy main group and f-block elements under aqueous conditions are described…

Inhibitors of the mitochondrial calcium uniporter (MCU) are valuable tools for studying the role of mitochondrial Ca2+ in various pathophysiological conditions. In this study, a ruthenium-based fluorogenic MCU inhibitor is presented…

The mitochondrial calcium uniporter (MCU), a transmembrane protein residing on the mitochondrial inner membrane, traffics calcium ions (Ca2+) into the mitochondrial matrix and is crucial in the maintenance of cellular function…

Hydrogen sulfide (H2S) is an endogenously-produced biological gasotransmitter that has therapeutic properties for a number of pathological conditions, including ischemia-reperfusion injury and stroke. The therapeutic value of H2S is limited by its inherent toxicity at high concentrations…

Hydrogen sulfide (H2S) is an endogenously produced gasotransmitter with untapped potential as a therapeutic in the treatment of various diseases and disorders, such as Parkinson's disease, inflammation, cancer, and ischemia-reperfusion injury…

Although the use of radiopharmaceutical agents has historically focused on diagnosis, recently it has extended into therapeutic applications with great clinical success…

The rare earth elements are critical minerals that are needed for many technological applications. Due to their similar chemical properties, in nature they are found within the same mineral deposits. Thus, separating the rare earth elements from each other is a challenging problem…

DIVISION/COMMITTEE: [INOR: Division of Inorganic Chemistry]

DIVISION/COMMITTEE: [INOR: Division of Inorganic Chemistry]

DIVISION/COMMITTEE: [INOR: Division of Inorganic Chemistry]

The rare earth elements are critical components within many modern technological devices. Their diverse f-electron configurations confer them with unique magnetic and electronic properties than render them valuable for these applications…

Radiometals are in growing demand for both nuclear imaging (PET or SPECT) and therapy of oncological diseases. For nuclear medicinal approaches, radiometals must form highly stable metal complexes to suppress cytotoxic effects of the free metal itself…

Targeted radionuclide therapy is a form of nuclear medicine that is being investigated for the treatment of cancer and other diseases. This therapeutic strategy requires a radiopharmaceutical agent that comprises a radionuclide, a biological targeting vector, and a chelating agent…