Iron is essential for nearly every organism, and mismanagement of its intracellular concentrations (either deficiency or excess) contributes to diminished virulence in human pathogens, necessitating intricate metalloregulatory mechanisms…
Lanmodulin (LanM) is the first natural lanthanide-selective chelator to be characterized, a protein with picomolar affinity for all rare earth elements…
The lanthanide-binding protein, lanmodulin (LanM), is a biomacromolecular ligand selective for rare earth elements (REEs). LanM holds a unique place in biology as it is the first biological ligand that exhibits both high affinity _and_ selectivity toward trivalent REEs…
The extraction and subsequent separation of individual rare earth elements (REEs) from REE-bearing feedstocks represents a challenging yet essential task for the growth and sustainability of renewable energy technologies…
The discovery that certain lanthanides are specifically utilized by biological systems has opened new avenues for development of selective, high-affinity chelators for purification of medically relevant f-elements and even potentially in vivo applications…
_Listeria monocytogenes _(_Lmo_) is a pathogenic bacterium responsible for food-borne illness. The bacterium uses the key enzyme, ribonucleotide reductase (RNR), to make deoxynucleotides, the building blocks of DNA, and to reproduce inside the host…
The selective recognition of metal ions is not only a biological necessity; it also has myriad applications in fields as diverse as mining and medicine…
Proper cellular metal homeostasis is required for normal growth and reproduction. Iron is one such metal micronutrient whose concentration must be tightly regulated in biology…
Manganese and magnesium are essential elements in living systems. Manganese serves as cofactor for various enzymes, including superoxide dismutase and class Ib ribonucleotide reductases, and is an integral component of the oxygen-evolving complex crucial for photosynthesis…
Lanthanide ions have been shown in the past decade to have catalytic and functional roles in certain bacteria. Lanthanides are also critical components of many modern technologies, and increasingly are being utilized in medicine as imaging agents and therapeutics…
The range of applications that rely on rare earth (RE) elements (Sc, Y, and La-Lu) is ever expanding. However, separating these elements from each other is challenging due to their similar chemical properties and frequent co-occurrence…
Amidst the escalating demand for rare earth elements (REEs) in green technologies, the purification of REEs remains challenging as they have similar physicochemical properties and co-occur in sources…
The discovery that certain lanthanides are specifically utilized by biological systems has opened new avenues for development of novel biochemistry-based strategies for highly selective recovery and separation of rare earth elements and actinides…
Rare earth element (REEs: Sc, Y, La- Lu) are irreplaceable components in many clean energy and consumer technologies. However, the extraction and subsequent separation of individual REEs from REE-bearing feedstocks remains a significant economic and environmental challenge…
Our previous work has shown enhanced intra-REE selectivity and separation performance of a lanmodulin ortholog, _Hans_-LanM, that dimerizes in a REE-dependent manner…