Prof. Jetze J. Tepe
Appearances
- DateApril 5, 2021SESSION: TOTAL SYNTHESIS OF COMPLEX MOLECULES:
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Graduate Research Assistant, Michigan State UniversitySpeaker
- Intrinsically disordered proteins (IDPs) are proteins that lack a defined tertiary structure in their native cellular environment. The 20S proteasome is charged with regulating cellular levels of these proteins, but this pathway can become dysregulated leading to their accumulation…
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Graduate Student, Michigan State UniversitySpeakers
PhD Candidate, Michigan State University - SESSION: CURRENT TOPICS IN BIOLOGICAL CHEMISTRY:
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- Currently, there are no available therapeutics to prevent or slow down the progression of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. Aggregates of disordered proteins are a common pathological feature of these neurodegenerative diseases…
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- DateJuly 8, 2021The pyrrole-guanidine natural products ugibohlin, 4-debromougibohlin and 5-debromougibohlin are marine metabolites containing a 1,5,6,7-tetrahydro-9_H_-pyrrolo[2,3-f]indolizin-9-one tricyclic ABC core common to many biologically active bromopyrrole alkaloids…
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Graduate Research Assistant, Michigan State UniversitySpeaker
- DateAugust 23, 2021The pyrrole-guanidine natural products ugibohlin, 4-debromougibohlin and 5-debromougibohlin are marine metabolites containing a 1,5,6,7-tetrahydro-9_H_-pyrrolo[2,3-f]indolizin-9-one tricyclic ABC core common to many biologically active bromopyrrole alkaloids…
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Graduate Research Assistant, Michigan State UniversitySpeaker
- DateAugust 24, 2021The pyrrole-guanidine natural products ugibohlin, 4-debromougibohlin and 5-debromougibohlin are marine metabolites containing a 1,5,6,7-tetrahydro-9_H_-pyrrolo[2,3-f]indolizin-9-one tricyclic ABC core common to many biologically active bromopyrrole alkaloids…
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Graduate Research Assistant, Michigan State UniversitySpeaker
- DateAugust 25, 2021Undruggable proteins are proteins that cannot be targeted pharmacologically. Undruggable proteins are deemed undruggable because they lack defined binding pockets and are therefore not suitable for traditional “small molecule-binding pocket” drug discovery approaches…
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- DateMarch 22, 2022Recently, a hexanucleotide repeat expansion (HRE) in a non-coding region of gene _C9ORF72 _has been identified as the most common cause of familial amyotrophic lateral sclerosis (ALS) and results in the production of five unique, highly disordered dipeptide repeat (DPR) proteins…
- DateMarch 20, 2022Intrinsically disordered proteins (IDPs) are proteins that lack a defined tertiary structure in their native cellular environment. The 20S proteasome is charged with regulating cellular levels of these proteins, but this pathway can become dysregulated leading to IDP accumulation…
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Graduate Student, Michigan State UniversitySpeaker
- DateMarch 24, 2022Neurodegenerative diseases effect millions of patients world-wide, however, there are insufficient available therapeutics to halt or slow down the progression of these diseases…
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- DateMarch 22, 2022Recently, a hexanucleotide repeat expansion (HRE) in a non-coding region of gene _C9ORF72 _has been identified as the most common cause of familial amyotrophic lateral sclerosis (ALS) and results in the production of five unique, highly disordered dipeptide repeat (DPR) proteins…
- DateAugust 23, 2022A hexanucleotide repeat expansion (HRE) in a non-coding region of gene _C9ORF72 _has recently been implicated as the most common cause of familial amyotrophic lateral sclerosis (ALS) cases…
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- DateAugust 21, 2022As we age, proteasome function decreases, resulting in the accumulation of intrinsically disordered proteins (IDPs), which has been directly linked to many neurodegenerative diseases…
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- DateAugust 21, 2022The urea- and guanidine-fused -piperazinone and -pyridone bicyclic moieties are a common feature found among pyrrole-alkaloid natural products…
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Graduate Research Assistant, Michigan State UniversitySpeaker
- DateAugust 24, 2022The indole-oxazole scaffold is found in a range of biologically active natural products including the breitfussins, pimprinines, labradorins, streptochlorin, and diazonamide A. These natural products all include an indole moiety connected at the C3 position to an oxazole’s C5 position…
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- DateAugust 23, 2022Marine sponges are inexhaustible producers of bromopyrrole alkaloids with various biological activities including anticancer, antibacterial and antiviral activities…
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- DateAugust 23, 2022As their name suggests, indole alkaloids are natural products that contain one or more indole structural moieties. Tulongicin is a tri-indole alkaloid that was isolated by Hong-Bing Liu from _Topsentia_ sp…
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- DateAugust 23, 2022Pyrrolopiperazinone scaffold is one of the salient features of bromopyrrole alkaloids possessing various biological activities, including cytotoxic, antibiotic, antitumor, and growth inhibitory activities against various cell lines…
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- A hexanucleotide repeat expansion (HRE) in an intron of gene _C9ORF72 _is the most common cause of familial amyotrophic lateral sclerosis (ALS) cases…
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- A hexanucleotide repeat expansion (HRE) in an intron of gene _C9ORF72 _is the most common cause of familial amyotrophic lateral sclerosis (ALS) cases…
- : [BIOL] Division of Biological Chemistry
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University of FloridaNC State UniversityUniversity of Illinois ChicagoPhD Student, The Ohio State UniversityWayne State UniversityAssistant Professor, Eastern Illinois UniversityThe Ohio State University - A hexanucleotide repeat expansion (HRE) in an intron of gene _C9ORF72 _is the most common cause of familial amyotrophic lateral sclerosis (ALS) cases…
- : [BIOL] Division of Biological Chemistry
Speakers
University of FloridaNC State UniversityUniversity of Illinois ChicagoPhD Student, The Ohio State UniversityWayne State UniversityAssistant Professor, Eastern Illinois UniversityThe Ohio State University - A hexanucleotide repeat expansion (HRE) in an intron of gene _C9ORF72 _is the most common cause of familial amyotrophic lateral sclerosis (ALS) cases…
- : [BIOL] Division of Biological Chemistry
Speakers
University of FloridaNC State UniversityUniversity of Illinois ChicagoPhD Student, The Ohio State UniversityWayne State UniversityAssistant Professor, Eastern Illinois UniversityThe Ohio State University - A hexanucleotide repeat expansion (HRE) in an intron of gene _C9ORF72 _is the most common cause of familial amyotrophic lateral sclerosis (ALS) cases…
- : [BIOL] Division of Biological Chemistry
Speakers
University of FloridaNC State UniversityUniversity of Illinois ChicagoPhD Student, The Ohio State UniversityWayne State UniversityAssistant Professor, Eastern Illinois UniversityThe Ohio State University - DateMarch 30, 2023A hexanucleotide repeat expansion (HRE) in an intron of gene _C9ORF72 _is the most common cause of familial amyotrophic lateral sclerosis (ALS) cases…
Presenter
- DateMarch 29, 2023Synucleinopathies are a sub-set of neurodegenerative diseases characterized by inclusions of α-synuclein in either neuronal cells, observed in Parkinson’s Disease (PD), or in oligodendrocytes, as seen in patients with Multiple System Atrophy (MSA)…
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- DateAugust 15, 2023Synucleinopathies are a subset of progressive neurodegenerative diseases. A defining characteristic of these neurodegenerative diseases is the formation of α-synuclein inclusions. They differ due to the location and strain of the α-synuclein aggregates…
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- DateAugust 15, 2023Familial amyotrophic lateral sclerosis (ALS) cases have been linked to a hexanucleotide repeat expansion (HRE) in an intron of gene _C9ORF72_…
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- DateMarch 26, 2025The progression of neurodegenerative disorders has been linked to the overproduction of intrinsically disordered proteins (IDPs), leading to toxic insoluble aggregates. Disruption of protein homeostasis due to impaired regulation of these proteins further exacerbates their accumulation…
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- DateAugust 18, 2025Alzheimer’s disease and its related dementias affect nearly seven million older adults and remain among the leading causes of death for this population…
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