The development of effective vaccines and antiviral treatments to prevent and manage symptoms of COVID-19 presents an optimistic short-term outlook for the ongoing pandemic; however, fundamental questions regarding the coronavirus life cycle including replication and genomic recombination events, a…
The need for environmentally friendly alternatives to metal catalysts continues to grow as their harmful impact on the environment and unsustainability become more apparent. One greener option is hydrogen bonding organocatalysts, which are typically inexpensive and made from renewable feedstocks…
Familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases genetically linked with a G4C2 hexanucleotide repeat expansion in the chromosome 9 open reading frame 72…
As expensive and rare transition metal catalysts become less sustainable, the organocatalysts recognized by the 2021 Nobel Prize in Chemistry are becoming increasingly attractive alternatives. Common organocatalyst cores include urea, thiourea, and squaramide…
As recognized by the 2021 Nobel Prize in Chemistry, urea and thiourea cores are commonly used to construct dual-hydrogen-bond-donor (DHBD) organocatalysts for important asymmetric organic reactions…
Endocrine disrupting chemicals (EDCs) disrupt the function of the androgen receptor (AR) leading to developmental problems for embryos and health problems for adults. The purpose of this work is to describe a mechanism for allosteric regulation of the androgen receptor by an EDC…
Endocrine disrupting chemicals (EDCs) disrupt the function of the androgen receptor (AR) leading to developmental problems for embryos and health problems for adults. The purpose of this work is to describe a mechanism for allosteric regulation of the androgen receptor by an EDC…
Endocrine disrupting chemicals (EDCs) disrupt the function of the androgen receptor (AR) leading to developmental problems for embryos and health problems for adults. The purpose of this work is to describe a mechanism for allosteric regulation of the androgen receptor by an EDC…
Urea and thiourea are common cores of dual-hydrogen-bond donor organocatalysts, a family of cost and energy efficient alternatives to toxic transition metal catalysts…
In reactions thought to involve 5-membered oxocarbenium ions, the identity of the substituent at the 3-position is key for the products to achieve high stereoselectivity…
The sustainability issues with rare earth transition metal catalysts are becoming increasingly clear due to their cost and negative environmental impacts. In response, asymmetric organocatalysts have become more attractive alternatives, garnering significant interest…
Coronaviruses are responsible for infections ranging from the common cold to Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and the current novel coronavirus (COVID-19) epidemics. The coronaviral genomes are large at nearly 30 kilobases…
Acetal substitution reactions are widely used for the synthesis of cyclic ethers, amines, and carbohydrates and proceed through oxocarbenium ion intermediates under acid catalysis…