Jason M Crawford

Dr. Crawford received his PhD in bioorganic chemistry at the Johns Hopkins University, studying the biosynthesis of genotoxins produced by eukaryotic iterative polyketide synthases. He conducted his postdoctoral training in biological chemistry and molecular pharmacology at Harvard Medical School where he focused on bioactive small molecule discovery, bacterial microbiology, and genetics in the context of biosynthetic gene clusters governing molecular interactions between bacteria and animals. He joined the departments of chemistry and of microbial pathogenesis at Yale University in 2012. The Crawford lab addresses two thematic biological questions at the human-bacteria interface, one from the microbial perspective and one from the host perspective: How do bacterial human/mouse microbiome members regulate host responses, such as inflammation, signal transduction, and DNA damage, at the metabolic level? And how do host cells, such as macrophages, employ immunometabolic pathways in response to microbial insults?