Dr. Jacob Devin Durrant PhD

My research focuses on developing and applying computational chemical biology tools to advance our understanding of protein dynamics and pharmacology. At the level of the binding pocket, I identify novel small-molecule ligands and characterize their poses and affinities. At the level of the protein, I use molecular-dynamics (MD) simulations to study how receptor motions impact molecular mechanisms, interactions, and allostery. My ultimate goal is to uncover information about these microscopic systems that can further the development of novel therapies.