My research focuses on assessing mechanistic roles for metabolism, bioactivation, and clearance of molecules in pharmacological and toxicological responses. My group develops and leverages powerful analytical, biochemical, and computational tools to identify and quantitate small molecules including drugs, dietary molecules, and pollutants during metabolism and correlate findings to biological activity and in vivo outcomes such as liver toxicity. Current research interests include studies on nonsteroidal anti-inflammatory drugs (NSAIDs), targeted cancer therapies, and drugs of abuse with special emphasis on kinase and bromodomain inhibitors and synthetic cannabinoid receptor agonists.