Session: Undergraduate Research Posters: Medicinal Chemistry:

This investigation will involve the synthesis of several putrescine analogs produced using 100% ethanol as the solvent. These nucleophilic substitution reactions with alkyl alcohol halides will produce bis(3-hydroxypropyl), bis(4-hydroxoybutyl), and bis(5-hydroxypentyl) putrescine. In this study, 100% ethanol was used as the reaction solvent this allowed for yields of the polyamine analogs to proceed in a greener solvent. There are many advantages to using alcohols over traditional volatile organic solvents in synthetic reactions. Alcohols are preferred solvents as they are more environmentally friendly, can be reclaimed or recycled, and reactions are run at lower temperatures. It was also found, in this work that the use of 100% ethanol increased the product yield dramatically over other more toxic alcohol solvents used for previous studies in our laboratory. The analog products were analyzed using FT-IR and FT-NMR. The antioxidant properties were measured and compared with standard antioxidants using a FRAP assay kit.

Francis Mayville

Appearances