Diwakar Shukla
University of Illinois at Urbana-Champaign
Appearances
DateApril 15, 2021Witchweed, or Striga hermonthica, is a parasitic weed that destroys billions of dollars worth of crops globally every year. Its germination is stimulated by strigolactones exuded by its host plants…Presenter
University of Illinois at Urbana-Champaign
DateApril 5, 2021Catalytic reactions at solid-liquid interfaces involve complex networks of adsorption, surface reaction, and desorption processes, where each possesses a free energy of reaction and activation that contributes to measured rates and selectivities…Presenter
Postdoctoral Researcher, MITSpeakers
Co-Founder and President, C2P Sciences L3CUniversity of Illinois at Urbana-ChampaignUniversity of Illinois
DateApril 7, 2021Division/Committee: [COMP] Division of Computers in ChemistryOrganizers
Seton Hall UniversityNational Taiwan UniversityPresider
University of Illinois at Urbana-Champaign
DateApril 7, 2021Cannabinoid receptor 1 (CB1) is a therapeutically relevant drug target for controlling pain, obesity, and other central nervous system disorders. However, full agonists and antagonists of CB1 have been reported to cause serious side effects in patients…Presenter
University of Illinois at Urbana-Champaign
DateApril 8, 2021The viral spike protein S binds ACE2 on host cells to initiate molecular events that release the viral genome intracellularly. Soluble ACE2 inhibits entry of both SARS and SARS-2 coronaviruses by acting as a decoy for S binding sites, and is a candidate for therapeutic and prophylactic development…Presenter
University of Illinois at Urbana-Champaign- DateAugust 24, 2021The rapid and escalating spread of SARS-CoV-2 poses an immediate public health emergency. The viral spike protein S binds ACE2 on host cells to initiate molecular events that release the viral genome intracellularly…
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University of Illinois at Urbana-Champaign - DateAugust 24, 2021Catalytic reactions at solid-liquid interfaces involve complex networks of adsorption, surface reaction, and desorption processes, where each possesses a free energy of reaction and activation that contributes to measured rates and selectivities…
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Postdoctoral Researcher, MITUniversity of Illinois at Urbana-ChampaignPresenter
University of Illinois - DateAugust 23, 2021The SWEET family belongs to a class of transporters in plants that undergoes large conformational changes to facilitate transport of sugar molecules across the cell membrane (SWEET, Sugars Will Eventually Be Exported Transporter)…
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University of Illinois at Urbana-Champaign - DateAugust 24, 2021Spectroscopic techniques such as Trp-Tyr quenching, Luminescence Resonance Energy Transfer, and Triplet-Triplet Energy Transfer are widely used for understanding the dynamic behavior of proteins…
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University of Illinois at Urbana-Champaign - DateMarch 22, 2022Solvating molecules and the environment that surround catalytic sites provide interactions that change rates and selectivities of catalytic events by orders of magnitude…
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Postdoctoral Researcher, MITNSF Graduate Research Fellow, UIUC - Flaherty LabUniversity of Illinois at Urbana-ChampaignPresenter
University of Illinois - DateMarch 21, 2022Parasitic activity of witchweed, or _Striga, _leads to a $10 billion loss per year of staple food crops and affects the livelihood of 100 million farmers worldwide…
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University of Illinois at Urbana-Champaign - DateMarch 24, 2022Witchweed, or _Striga hermonthica_ is a parasite that destroys ~$10 billion worth of crops annually…
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University of Illinois at Urbana-Champaign - DateMarch 22, 2022Excipients are a major component of drugs and are used to improve drugs attributes such as stability and appearance…
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University of Illinois at Urbana-Champaign - DateAugust 23, 2022The endocannabinoid systems consist of receptors (Cannabinoid receptor 1, CB1; Cannabinoid receptor 2, CB2;), endogenous molecules (endocannabinoids), and enzymes that regulate essential physiological and psychological processes…
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University of Illinois at Urbana-Champaign - DateAugust 21, 2022Smoothened (SMO) is a membrane protein of the Class F subfamily of G-Protein Coupled Receptors (GPCRs) and maintains homeostasis of cellular differentiation. SMO undergoes activation, transmitting signals across the membrane making it amenable to bind to its intracellular binding partner…
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University of Illinois at Urbana-Champaign - DateAugust 21, 2022Molecular Dynamics (MD) simulations have become a crucial tool in chemistry, biology, condensed matter physics, and materials science. Given the unfavorable asymptotic behavior of Amdahl’s Law, researchers typically run parallel MD simulations to leverage the computational power of large clusters…
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Ph.D. Candidate, University of Illinois, Urbana-ChampaignSpeaker
University of Illinois at Urbana-Champaign - DateAugust 24, 2022Transporters are targeted by endogenous metabolites and exogenous molecules to reach cellular destinations. More importantly, atomistic detail as to how different substrate classes exploit the same transporter’s molecular mechanism is lacking…
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University of Illinois at Urbana-Champaign - DateAugust 24, 2022Antibiotic resistance of Gram-negative bacteria is largely attributed to the low permeability of their outer membrane (OM). Effective antibiotics typically permeate OM porins; thus, understanding porin permeation mechanisms would aid antibiotic development…
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University of Illinois at Urbana-Champaign - DateAugust 24, 2022Monoamine transporters are sodium dependent transmembrane proteins responsible for the reuptake of neurotransmitters from the synaptic cleft…
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University of Illinois at Urbana-Champaign - DateAugust 23, 2022The human immunodeficiency virus (HIV) can irreversibly integrate a DNA copy of its genome into the infected host-cell genome and enter a prolonged and inactive latent state…
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- Class B G-Protein Coupled Receptors consist of the peptide-binding membrane proteins in the GPCR superfamily…
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University of Illinois at Urbana-Champaign - Deep mutagenesis, whereby tens of thousands of mutational effects are determined by combining in vitro selections of sequence variants with Illumina sequencing, is an emerging technology for indirectly interrogating and observing protein conformations in living cells…
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University of Illinois at Urbana-Champaign - Lanthipeptides are ribosomally synthesized and post-translationally modified peptides that are generated from precursor peptides through a dehydration and cyclization process in the biosynthetic pathways…
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- With increasing regulations on per- and polyfluoroalkyl substances (PFAS) across the world, understanding the molecular level interactions that drive their binding by functional adsorbent materials is key to effective PFAS removal from water streams…
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Phd Candidate, University of Illinois Urbana ChampaignSpeakers
University of Illinois at Urbana-ChampaignUniversity of Illinois at Urbana-Champaign - Assessing the effect of mutations on protein function is a central question in protein engineering. The rise in popularity of machine learning approaches and its integration in the field of molecular biology gave rise to many advanced but uninterpretable models for assessing the effects of mutation…
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University of Illinois at Urbana-Champaign - METHODS DEVELOPMENT FOR THE RAPID EXPLORATION OF THE CONFORMATIONAL ENSEMBLE OF BIOLOGICAL MOLECULES REMAINS AN ACTIVE AREA OF RESEARCH DUE TO THE DIFFICULTY OF SAMPLING RARE STATE TRANSITIONS IN MOLECULAR DYNAMICS (MD) SIMULATIONS…
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Ph.D. Candidate, University of Illinois, Urbana-ChampaignSpeaker
University of Illinois at Urbana-Champaign - Class B G-Protein Coupled Receptors consist of the peptide-binding membrane proteins in the GPCR superfamily…
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University of Illinois at Urbana-Champaign - Class B G-Protein Coupled Receptors consist of the peptide-binding membrane proteins in the GPCR superfamily…
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University of Illinois at Urbana-Champaign - : [BIOL] Division of Biological Chemistry
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University of FloridaNC State UniversityGeorgia TechPostdoc Research Fellow, Carnegie Mellon UniversityGraduate Student, University of VictoriaUniversity of Illinois at Urbana-ChampaignThe Pennsylvania State University - University Park CampusIndiana University - Class B G-Protein Coupled Receptors consist of the peptide-binding membrane proteins in the GPCR superfamily…
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University of Illinois at Urbana-Champaign - : [BIOL] Division of Biological Chemistry
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University of FloridaNC State UniversityGeorgia TechPostdoc Research Fellow, Carnegie Mellon UniversityGraduate Student, University of VictoriaUniversity of Illinois at Urbana-ChampaignThe Pennsylvania State University - University Park CampusIndiana University - Class B G-Protein Coupled Receptors consist of the peptide-binding membrane proteins in the GPCR superfamily…
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University of Illinois at Urbana-Champaign - : [BIOL] Division of Biological Chemistry
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University of FloridaNC State UniversityGeorgia TechPostdoc Research Fellow, Carnegie Mellon UniversityGraduate Student, University of VictoriaUniversity of Illinois at Urbana-ChampaignThe Pennsylvania State University - University Park CampusIndiana University - Deep mutagenesis, whereby tens of thousands of mutational effects are determined by combining in vitro selections of sequence variants with Illumina sequencing, is an emerging technology for indirectly interrogating and observing protein conformations in living cells…
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University of Illinois at Urbana-Champaign - : [COMP] Division of Computers in Chemistry
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Associate Professor, Western University of Health SciencesTemple UniversityUniversity of Illinois at Urbana-ChampaignAssociate Professor, Rowan University - Lanthipeptides are ribosomally synthesized and post-translationally modified peptides that are generated from precursor peptides through a dehydration and cyclization process in the biosynthetic pathways…
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University of Illinois at Urbana-Champaign - : [COMP] Division of Computers in Chemistry
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Associate Professor, Western University of Health SciencesUniversity of California San DiegoTemple UniversityThe University of Texas at DallasWayne State UniversityUniversity of Texas at ArlingtonUniversity of Illinois at Urbana-ChampaignCarlos Simmerling, PhDProfessor, SUNY Stony BrookPostdoctoral Research Scholar, University of California, San DiegoUniversity of California, San DiegoArizona State University - : [COMP] Division of Computers in Chemistry
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University of South FloridaAssociate Professor, Messiah CollegeIndiana Univ Purdue Univ IndianapolisUniversity of KentuckyAssociate Professor of Chemistry, University of KentuckyBrooklyn CollegeUniversity of PittsburghUniversity of Texas at El Paso University Research InstituteGeorgia Institute of TechnologyGeorgia Institute of TechPhD student, Carnegie Mellon UniversityPhD Student, Carnegie Mellon UniversityCarnegie Mellon UniversityUniversity of AkronAssociate Professor of Chemistry, Missouri State UniversityRutgers The State University of New JerseyResearch Scientist, Lawrence Berkeley National LaboratoryE O Lawrence Berkeley National LaboratoryAssistant Professor, Massachusetts Institute of TechnologyRutgers UniversityGraduate Student, University of Minnesota Twin CitiesUC BerkeleyUC BerkeleyPostdoctoral Associate, University of MinnesotaUniversity of MinnesotaMassachusetts Institute of TechnologyThe University of Texas at DallasWayne State UniversityCatalytic principles from natural enzymes for design of synthetic catalystsUniversity of MissouriUniversity of California San DiegoPostdoctoral Research Scholar, University of California, San DiegoUniversity of California, San DiegoRice UniversityGraduate Student, University of VictoriaUniversity of MarylandProfessor, Uppsala UniversityRheinisch Westfalische Technische Hochschule Aachen Fakultat fur Mathematik Informatik und NaturwissenschaftenHead of Lab Linked Scientific Knowledge, Technische InformationsbibliothekCalifornia Institute of TechnologyUniversity of California RiversideUniversity of CaliforniaGraduate Student, Rutgers UniversityUniv of Ontario Inst of TechSchrodinger IncMathew D. Halls, Ph.D.Senior Vice President, Materials Science, Schrödinger, Inc.Assistant Professor, Missouri State UniversityAssociate Professor, University of KansasPh.D. Student, Massachusetts Institute of TechnologyStony Brook UniversityCarlos Simmerling, PhDProfessor, SUNY Stony BrookProfessor, Indian Institute of Technology KharagpurAssociate Professor, Western University of Health SciencesAssociate Professor of Chemistry, Centenary UniversityPhD Student, Indian Institute of Technology JammuPennsylvania State UnivTexas A&M UniversityNationwide Children's HospitalUniv. of Maryland, PharmacyUniversity of PittsburghUniv of North CarolinaAssistant Professor, Eastern Illinois UniversityUniversity of Texas at DallasBrown UnivUniversity of South FloridaThe University of OklahomaUniversity of Kentucky College of Arts and SciencesChemistry Graduate Student, University of IowaUniversity of IowaThe University of MississippiPurdue UniversityAssistant Professor, University of FindlayAssociate Professor of Chemistry, University of FindlayJohns Hopkins UniversityJohns Hopkins UniversityUniversity of Illinois at Urbana-ChampaignUniversity of MinnesotaThe University of MemphisClarkson UniversityApplication Scientist, OptibriumLafayette CollegeIndian Institute of Technology DelhiUniversity of Wisconsin-Eau ClaireComputational Scientist, Pacific Nortwest National LaboratoryGraduate Student Researcher, University of California San DiegoUniversity of PittsburghMichigan State UniversityArgonne National LaboratoryMichigan State UniversityPostdoctoral Research Scholar, Michigan State UniversityMichigan State UniversityStaff Scientist, Sandia National LabsArizona State UniversityProfessor, Haverford CollegeNorth Dakota State UniversityAssociate Professor, North Dakota State UniversityPennsylvania State UniversityTexas A&M UnivIndiana UnivOld Dominion UniversityNorth Dakota State UniversityAssistant Professor, University of South Carolina SystemFlorida Gulf Coast UniversityAssociate Professor, Texas A&M University SystemSyracuse UniversityAssistant Professor, Oakland UniversityNorth Carolina State University - With increasing regulations on per- and polyfluoroalkyl substances (PFAS) across the world, understanding the molecular level interactions that drive their binding by functional adsorbent materials is key to effective PFAS removal from water streams…
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Phd Candidate, University of Illinois Urbana ChampaignUniversity of Illinois at Urbana-ChampaignUniversity of Illinois at Urbana-Champaign - : [ENVR] Division of Environmental Chemistry
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US EPASenior Chemical Engineeri, U,S Environmental Protection AgencyProfessor, Georgia Institute of TechnologyColorado School of MinesPhd Candidate, University of Illinois Urbana ChampaignUniversity of Illinois at Urbana-ChampaignUniversity of Illinois at Urbana-ChampaignAssistant Research Professor, Arizona State UniversityPh.D. student, Texas A&M UniversityRegent Professor, Arizona State Univ - Class B G-Protein Coupled Receptors consist of the peptide-binding membrane proteins in the GPCR superfamily…
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University of Illinois at Urbana-Champaign - : [BIOL] Division of Biological Chemistry
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University of FloridaNC State UniversityGeorgia TechPostdoc Research Fellow, Carnegie Mellon UniversityGraduate Student, University of VictoriaUniversity of Illinois at Urbana-ChampaignThe Pennsylvania State University - University Park CampusIndiana University - Deep mutagenesis, whereby tens of thousands of mutational effects are determined by combining in vitro selections of sequence variants with Illumina sequencing, is an emerging technology for indirectly interrogating and observing protein conformations in living cells…
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University of Illinois at Urbana-Champaign - : [COMP] Division of Computers in Chemistry
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Associate Professor, Western University of Health SciencesTemple UniversityUniversity of Illinois at Urbana-ChampaignAssociate Professor, Rowan University - Lanthipeptides are ribosomally synthesized and post-translationally modified peptides that are generated from precursor peptides through a dehydration and cyclization process in the biosynthetic pathways…
Speakers
University of Illinois at Urbana-Champaign - : [COMP] Division of Computers in Chemistry
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Associate Professor, Western University of Health SciencesUniversity of California San DiegoTemple UniversityThe University of Texas at DallasWayne State UniversityUniversity of Texas at ArlingtonUniversity of Illinois at Urbana-ChampaignCarlos Simmerling, PhDProfessor, SUNY Stony BrookPostdoctoral Research Scholar, University of California, San DiegoUniversity of California, San DiegoArizona State University - : [COMP] Division of Computers in Chemistry
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University of South FloridaAssociate Professor, Messiah CollegeIndiana Univ Purdue Univ IndianapolisUniversity of KentuckyAssociate Professor of Chemistry, University of KentuckyBrooklyn CollegeUniversity of PittsburghUniversity of Texas at El Paso University Research InstituteGeorgia Institute of TechnologyGeorgia Institute of TechPhD student, Carnegie Mellon UniversityPhD Student, Carnegie Mellon UniversityCarnegie Mellon UniversityUniversity of AkronAssociate Professor of Chemistry, Missouri State UniversityRutgers The State University of New JerseyResearch Scientist, Lawrence Berkeley National LaboratoryE O Lawrence Berkeley National LaboratoryAssistant Professor, Massachusetts Institute of TechnologyRutgers UniversityGraduate Student, University of Minnesota Twin CitiesUC BerkeleyUC BerkeleyPostdoctoral Associate, University of MinnesotaUniversity of MinnesotaMassachusetts Institute of TechnologyThe University of Texas at DallasWayne State UniversityCatalytic principles from natural enzymes for design of synthetic catalystsUniversity of MissouriUniversity of California San DiegoPostdoctoral Research Scholar, University of California, San DiegoUniversity of California, San DiegoRice UniversityGraduate Student, University of VictoriaUniversity of MarylandProfessor, Uppsala UniversityRheinisch Westfalische Technische Hochschule Aachen Fakultat fur Mathematik Informatik und NaturwissenschaftenHead of Lab Linked Scientific Knowledge, Technische InformationsbibliothekCalifornia Institute of TechnologyUniversity of California RiversideUniversity of CaliforniaGraduate Student, Rutgers UniversityUniv of Ontario Inst of TechSchrodinger IncMathew D. Halls, Ph.D.Senior Vice President, Materials Science, Schrödinger, Inc.Assistant Professor, Missouri State UniversityAssociate Professor, University of KansasPh.D. Student, Massachusetts Institute of TechnologyStony Brook UniversityCarlos Simmerling, PhDProfessor, SUNY Stony BrookProfessor, Indian Institute of Technology KharagpurAssociate Professor, Western University of Health SciencesAssociate Professor of Chemistry, Centenary UniversityPhD Student, Indian Institute of Technology JammuPennsylvania State UnivTexas A&M UniversityNationwide Children's HospitalUniv. of Maryland, PharmacyUniversity of PittsburghUniv of North CarolinaAssistant Professor, Eastern Illinois UniversityUniversity of Texas at DallasBrown UnivUniversity of South FloridaThe University of OklahomaUniversity of Kentucky College of Arts and SciencesChemistry Graduate Student, University of IowaUniversity of IowaThe University of MississippiPurdue UniversityAssistant Professor, University of FindlayAssociate Professor of Chemistry, University of FindlayJohns Hopkins UniversityJohns Hopkins UniversityUniversity of Illinois at Urbana-ChampaignUniversity of MinnesotaThe University of MemphisClarkson UniversityApplication Scientist, OptibriumLafayette CollegeIndian Institute of Technology DelhiUniversity of Wisconsin-Eau ClaireComputational Scientist, Pacific Nortwest National LaboratoryGraduate Student Researcher, University of California San DiegoUniversity of PittsburghMichigan State UniversityArgonne National LaboratoryMichigan State UniversityPostdoctoral Research Scholar, Michigan State UniversityMichigan State UniversityStaff Scientist, Sandia National LabsArizona State UniversityProfessor, Haverford CollegeNorth Dakota State UniversityAssociate Professor, North Dakota State UniversityPennsylvania State UniversityTexas A&M UnivIndiana UnivOld Dominion UniversityNorth Dakota State UniversityAssistant Professor, University of South Carolina SystemFlorida Gulf Coast UniversityAssociate Professor, Texas A&M University SystemSyracuse UniversityAssistant Professor, Oakland UniversityNorth Carolina State University - With increasing regulations on per- and polyfluoroalkyl substances (PFAS) across the world, understanding the molecular level interactions that drive their binding by functional adsorbent materials is key to effective PFAS removal from water streams…
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Phd Candidate, University of Illinois Urbana ChampaignUniversity of Illinois at Urbana-ChampaignUniversity of Illinois at Urbana-Champaign - : [ENVR] Division of Environmental Chemistry
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US EPASenior Chemical Engineeri, U,S Environmental Protection AgencyProfessor, Georgia Institute of TechnologyColorado School of MinesPhd Candidate, University of Illinois Urbana ChampaignUniversity of Illinois at Urbana-ChampaignUniversity of Illinois at Urbana-ChampaignAssistant Research Professor, Arizona State UniversityPh.D. student, Texas A&M UniversityRegent Professor, Arizona State Univ - DateMarch 28, 2023Class B G-Protein Coupled Receptors consist of the peptide-binding membrane proteins in the GPCR superfamily…
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University of Illinois at Urbana-Champaign - DateMarch 26, 2023Deep mutagenesis, whereby tens of thousands of mutational effects are determined by combining in vitro selections of sequence variants with Illumina sequencing, is an emerging technology for indirectly interrogating and observing protein conformations in living cells…
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University of Illinois at Urbana-Champaign - DateMarch 27, 2023Lanthipeptides are ribosomally synthesized and post-translationally modified peptides that are generated from precursor peptides through a dehydration and cyclization process in the biosynthetic pathways…
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- DateMarch 28, 2023Molecular dynamics (MD) simulations are widely implemented to study protein dynamics, but simulation results for membrane protein systems are largely confounded by the selected model lipid bilayer…
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University of Illinois at Urbana-Champaign - DateMarch 27, 2023With increasing regulations on per- and polyfluoroalkyl substances (PFAS) across the world, understanding the molecular level interactions that drive their binding by functional adsorbent materials is key to effective PFAS removal from water streams…
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Phd Candidate, University of Illinois Urbana ChampaignSpeakers
University of Illinois at Urbana-ChampaignUniversity of Illinois at Urbana-Champaign - DateMarch 28, 2023Assessing the effect of mutations on protein function is a central question in protein engineering. The rise in popularity of machine learning approaches and its integration in the field of molecular biology gave rise to many advanced but uninterpretable models for assessing the effects of mutation…
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Speaker
University of Illinois at Urbana-Champaign - DateMarch 28, 2023Methods development for the rapid exploration of the conformational ensemble of biological molecules remains an active area of research due to the difficulty of sampling rare state transitions in Molecular Dynamics (MD) simulations…
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Ph.D. Candidate, University of Illinois, Urbana-ChampaignSpeaker
University of Illinois at Urbana-Champaign - DateAugust 17, 2023Cannabinoid receptors (CBs) are part of the endocannabinoid signaling system, which helps to maintain homeostasis in neuron signaling to control pain, obesity, and other neurological disorders…
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University of Illinois at Urbana-Champaign - DateAugust 15, 2023Membrane transporters are known to uptake and export molecules outside of their known substrate scopes (e.g., transport of exogenous drugs or foreign substances to a host proteome). Therefore, membrane transporter mechanisms must demonstrate some plasticity to transport a variety of molecules…
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University of Illinois at Urbana-Champaign - DateAugust 15, 2023Plant BAHD acyltransferases (PF02458) serve as a unique case study in enzymatic promiscuity and specialization. This class of enzymes has evolved to handle a variety of basal and specialized metabolic biosyntheses while undergoing rapid sequence divergence…
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University of Illinois at Urbana-Champaign - DateAugust 15, 2023Drug discovery is a challenging process consisting of a series of steps from target identification to final approval. The molecule space of potential drug candidates is estimated to be more than 1060. However, screening the entire space with existing computational techniques is impossible…
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University of Illinois at Urbana-Champaign - DateMarch 17, 2024Rapid computational exploration of the free energy landscape of biological molecules remains an active area of research due to the difficulty of sampling rare state transitions in molecular dynamics (MD) simulations…
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University of Illinois at Urbana-Champaign - DateMarch 18, 2024Monoamine transporters are sodium dependent transmembrane proteins responsible for the reuptake of neurotransmitters from the synaptic cleft…
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University of Illinois at Urbana-Champaign - DateMarch 19, 2024Membrane transporters are known to uptake and export molecules outside of their known substrate scopes (e.g., transport of exogenous drugs or foreign substances to a host proteome). Therefore, membrane transporter mechanisms must demonstrate some plasticity to transport a variety of molecules…
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University of Illinois at Urbana-Champaign - DateAugust 18, 2024Ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic enzymes often exhibit promiscuous substrate preferences that cannot be reduced to simple rules. Large language models are promising tools for predicting such peptide fitness landscapes…
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- DateAugust 20, 2024Ribosomally synthesized and post-translationally modified peptides (RiPPs) contain a diverse class of peptide natural products exhibiting remarkable bioactivities ranging from anticancer to anti-infective and analgestic effects…
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University of Illinois at Urbana-Champaign - DateMarch 26, 2025Peptide brush polymers are proteomimetics generated by graft-through living polymerization that exhibit emergent properties lending utility as therapeutics, chemical biology tools, and adhesive materials…
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Northwestern UniversityCo-Authors
University of Illinois at Urbana-Champaign - DateMarch 25, 2025Smoothened (SMO) acts as the primary transducer of the Hedgehog signaling pathway in response to the accessible cholesterol in the ciliary membrane. How cholesterol from the membrane is transported via a longitudinal tunnel in SMO to its orthosteric binding site remains unknown…
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