The inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents and pesticides is, thankfully, reversible with the treatment of reactivators, such as 2-pralidoxime (2-PAM)…
Acetylcholinesterase (AChE) is a vital serine hydrolase found throughout the body and it is responsible for the catalytic hydrolysis of the neurotransmitter acetylcholine…
Organophosphates (OPs) have been in recent news with several emerging cases of nerve agent poisoning of significant personalities and national leaders…
Organophosphorus (OP) compounds such as pesticides and chemical warfare agents primarily target the enzyme acetylcholinesterase (AChE) in the human body. AChE is a hydrolytic enzyme responsible for the degradation of the neurotransmitter acetylcholine…
Organophosphorus (OP) compounds such as pesticides and chemical warfare agents primarily target the enzyme acetylcholinesterase (AChE) in the human body. AChE is a hydrolytic enzyme responsible for the degradation of the neurotransmitter acetylcholine…
Organophosphorus (OP) compounds such as pesticides and chemical warfare agents primarily target the enzyme acetylcholinesterase (AChE) in the human body. AChE is a hydrolytic enzyme responsible for the degradation of the neurotransmitter acetylcholine…
Organophosphorus (OP) compounds such as pesticides and chemical warfare agents primarily target the enzyme acetylcholinesterase (AChE) in the human body. AChE is a hydrolytic enzyme responsible for the degradation of the neurotransmitter acetylcholine…
Organophosphorus (OP) compounds such as pesticides and chemical warfare agents primarily target the enzyme acetylcholinesterase (AChE) in the human body. AChE is a hydrolytic enzyme responsible for the degradation of the neurotransmitter acetylcholine…
Organophosphorus (OP) compounds such as pesticides and chemical warfare agents primarily target the enzyme acetylcholinesterase (AChE) in the human body. AChE is a hydrolytic enzyme responsible for the degradation of the neurotransmitter acetylcholine…
Organophosphorus (OP) agents are responsible for the inhibition of the enzyme acetylcholinesterase (AChE) which is found in erythrocytes, brain synapses, and neuromuscular junctions. AChE contains a catalytic triad of serine-histidine-glutamate residues located within the enzyme active site…
Acetylcholinesterase (AChE) is an enzyme in the body found primarily in erythrocytes, brain synapses, and neuromuscular junctions. Located in the active site of the enzyme, the triad of serine, histidine, and glutamate is where selective hydrolysis of the neurotransmitter acetylcholine occurs…
Drug molecules targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could save millions of lives from COVID-19 pandemic, and the USFDA has authorized emergency use of Paxlovid, an investigational medicine, for the treatment of mild-to-moderate COVID-19 in adults and children…
Organophosphorus (OP) compounds such as herbicides and pesticides pose a threat because of their toxicity in cholinesterase inhibition. OP compounds inhibit acetylcholinesterase (AChE) by phosphylation of the catalytic serine residue, resulting in cholinergic crisis and potential death…
Organophosphorus (OP) compounds have toxicity and inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), leading to a cholinergic crisis and possibly death. The OP-inhibited cholinesterases undergo spontaneous _O_-dealkylations, generating the OP-aged forms…
Acetylcholinesterase (AChE) is an important enzyme for human health. AChE relaxes nerve impulses through hydrolysis of the neurotransmitter acetylcholine. Organophosphorus (OP) compounds are toxic due to their ability to inhibit and age AChE, which induces a cholinergic crisis…
Organophosphorus (OP) compounds have been used around the world throughout the twentieth century, often with deadly consequences, while organophosphate pesticides have been used predominantly in developing countries and are often produced on large scales…