Division/Committee: [BIOT: Division of Biochemical Technology]

Mammalian cell culture is crucial for producing viral vaccines, recombinant proteins, monoclonal antibodies, and biopharmaceuticals. The rise of cell-based and gene therapies, involving cells or viral capsids encoding genes of interest, further emphasizes the need for optimal culture conditions. The interplay between mammalian cell growth, nutrient-enhanced media, and the physicochemical environment has matured the field into a multi-disciplinary collaborative effort including advancements in genetic manipulation, medium and feed development, bioreactor characterization, and process control to enhance productivity, product quality and other interrelated areas. This session covers various aspects of mammalian cell culture development, including improved production vectors, novel clone selection, host cell line engineering, cell expansion strategies, metabolic pathway analysis, media development, multivariate process analysis, and innovative cell culture process development. Relevant papers are encouraged, particularly those on cell line development, vector engineering, medium optimization, preparation, storage and chemistry, metabolic engineering, modelling, 'omics analyses, and management of raw material changes in media components.

Chun Chen

Bill & Melinda Gates Medical Research Institute

Appearances