Division/Committee: [BIOT] Division of Biochemical Technology

This session hosts contributions focusing on practical and theoretical approaches that advance and optimize antibody purification platforms. Topics include broadening platform applicability across the full range of novel process technologies and modes of chromatographic operation. These topics include but are not limited to: (i) continuous vs. batch modes of purification for process intensification; (ii) scale-down and high-throughput methodologies to evaluate platform fit for antibody candidates; (iii) scale-up/process implementation to enable rapid and robust process transfer to manufacturing facilities; (iv) novel integrative processes (e.g., ATPS, precipitation, and crystallization); (v) utilization of biophysical structure models and large portfolios of data to make process predictions and other “big data” approaches; and (vi) mechanistic and molecular-level characterization of critical separation challenges. These separation challenges could include: post-translational modifications (e.g., charge, glycosylation, etc.); antibody-related product variants (e.g., aggregates, clipped forms and fragments, etc.); and process-related impurities (e.g., difficult-to-remove HCPs, DNA, viruses and endotoxins, etc.).

Christian Dr. Frech

Hochschule Mannheim

Appearances