The inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents and pesticides is, thankfully, reversible with the treatment of reactivators, such as 2-pralidoxime (2-PAM)…
Acetylcholinesterase (AChE) is an enzyme in the body found primarily in erythrocytes, brain synapses, and neuromuscular junctions. Located in the active site of the enzyme, the triad of serine, histidine, and glutamate is where selective hydrolysis of the neurotransmitter acetylcholine occurs…