One of the O-GlcNAcmodifications is the protection of cells against a variety of stressors that result in cell death. Previous experiments have focused on the over all ability of O-GlcNAc to prevent protein aggregation under stress as well as its ability to affect stress-response signaling pathways…
The intrinsically disordered protein α-Synuclein is a key aggregate in Parkinson’s and other neurodegenerative diseases. Recent studies have explored how posttranslational modifications impact its aggregation kinetics, with O-GlcNAcylation shown to inhibit aggregation…