Adenosine triphosphate (ATP) is an important biochemical molecule, due to its role in many biological pathways. It’s hydrolysis energizes most metabolic pathways. Understanding ATP’s biological role requires studies on the stability of the molecule at varying pH conditions…
Enolization of substituted acetic acids using dialkylboron halides followed by aldolization with aldehydes and ketones provides the corresponding β-hydroxyacids in very good yields and anti selectivities…
Chlorodicyclohexyl-borane and triethylamine-mediated aldol reaction of chloroacetic acid with ketones, aldehydes, and imines provided a series of α-chloro-β-hydroxy/amino acids in excellent yields and anti stereoselectivity…
The esterification of fatty acids into alkyl (R) esters is a common analytical technique in gas chromatography mass spectrometry (GC-MS). This technique reduces analyte adsorption to the chromatographic column thereby improving analyte separation…
The esterification of fatty acids into alkyl (R) esters is a common analytical technique in gas chromatography mass spectrometry (GC-MS). This technique reduces analyte adsorption to the chromatographic column thereby improving analyte separation…
The esterification of fatty acids into alkyl (R) esters is a common analytical technique in gas chromatography mass spectrometry (GC-MS). This technique reduces analyte adsorption to the chromatographic column thereby improving analyte separation…
Integrating course-based undergraduate research experiences (CUREs) into upper-level chemistry courses is becoming increasingly popular. The benefits of such courses include increased student self-confidence, scientific research skills, and critical thinking…
The esterification of fatty acids into alkyl (R) esters is a common analytical technique in gas chromatography mass spectrometry (GC-MS). This technique reduces analyte adsorption to the chromatographic column thereby improving analyte separation…
Integrating course-based undergraduate research experiences (CUREs) into upper-level chemistry courses is becoming increasingly popular. The benefits of such courses include increased student self-confidence, scientific research skills, and critical thinking…
The critical role of stereochemistry in life and industrial/pharmaceutical chemistry mandates that stereochemistry is well represented in undergraduate lab curricula…
The esterification of fatty acids into alkyl (R) esters is a common analytical technique in gas chromatography mass spectrometry (GC-MS). This technique reduces analyte adsorption to the chromatographic column thereby improving analyte separation…
Three novel approaches towards the synthesis of analogs of fluoxetine (prozac) were proposed and investigated as part of the research inspired organic laboratory experience…
An attempted oxa-michael addition of 4-fluorophenol to cinnamaldehyde using scandium triflate as catalyst has resulted in nucleophilic aromatic addition of the hydroxy-activated phenol to the cinnamaldehyde aromatic ring instead of the expected michael position…
9-borabicyclo [3.3.1] nonane (9-BBN) is a versatile reagent used to synthesize numerous drugs and chemicals. Despite its versatility and relative ease of handling, it is relatively expensive and does not provide asymmetry in its reactions…
9-Borabicyclo[3.3.1]nonane (9-BBN) is a versatile reagent widely used in the synthesis of various drugs and chemicals. Despite its utility and ease of handling, 9-BBN is relatively expensive and lacks asymmetry in its reactions…
β-lactones are the ester analogs to cyclic 4-membered carboxylic amides, β-lactams, the most common chemical moiety in antibiotics. Many β-lactones have been found to have antibiotic or otherwise medically beneficial properties. However, only a few β-lactone drugs are currently on the market…
Electrophilic aromatic substitution reactions are pivotal in organic chemistry, relying on low-energy cations to temporarily disrupt aromatic systems. However, generating carbocations often poses significant challenges, such as rearrangements and β-elimination byproducts…
9-BBN is an important compound in the synthesis of terminal alcohols by providing high regioselectivity for the anti-Markovnikov position. It is also used as a reducing agent for ketones and aldehydes and various alkyl ligation reactions…